Synthesis and general properties of silated-hydroxypropyl methylcellulose in prospect of biomedical use

Bourges, Xavier; Weiss, Pierre; Daculsi, Guy; Legeay, G.

doi:10.1016/s0001-8686(02)00035-0

Cited by 111 publications

(101 citation statements)

References 26 publications

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“…In general, the crosslinking kinetics depend on temperature and pH . In this study [8 ] we showed, at a fixed pH and temperature, the influence of dilution. A dependence of final concentration of HPMC-Si hydrogel on crosslinking kinetics and viscoelastic properties was observed.…”

Section: ] ′mentioning

confidence: 74%

“…The limiting pH of ' − − + [9 ] sodium silanolate stabilization is approximately 12.1~12.2, below which sodium silanolates transform into silanols ( SiOH) . These − [8 ] lasts can undergo condensation reactions, forming a three-dimensional network of the HPMC-Si chains ( ). The first synthesis of Fig.…”

Section: Icpcs Was Developedmentioning

confidence: 99%

“…The [11 12 ] et al [13 ] principle of synthesis and kinetics of crosslinking of HPMC-Si were largely described by Bourges . et al [8 ] 2 16 The aim of this work was to characterize the influence of silanisation of HPMC on the rheological properties of the solution and to study the kinetics of gelation of HPMC-Si using oscillatory shear rheometry. Studies were conducted first to determine the difference between nongrafted HPMC and silated HPMC under different forms: (i) powders using vibrational spectroscopy (Fourier transform infrared and Fourier transform Raman) (ii) dilute solutions using intrinsic viscosity measurements, and (iii) concentrated solutions using rheological measurements (flow curves and oscillatory frequency sweeps).…”

Section: Icpcs Was Developedmentioning

confidence: 99%

“…The Table 1 The principle of HPMC-Si synthesis was largely described by Bourges . 1.91 of -heptane (Acros, Belgium) were stirred et al [8 ] n with 420 ml of 1-Propanol (Acros, Belgium). 12 g of NaOH (Prolabo, France) and 240 g of dry HPMC were added to the mixture under stirring.…”

Section: Synthesis Of Hpmc-simentioning

confidence: 99%

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The rheological properties of silated hydroxypropylmethylcellulose tissue engineering matrices

et al. 2008

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International audienceThis paper describes the rheological properties of silated hydroxypropylmethylcellulose (HPMC-Si) used in biomaterials domain as a three-dimensional synthetic matrix for tissue engineering. The HPMC-Si is an HPMC grafted with 3-glycidoxypropyltrimethoxysilane (GPTMS). HPMC and HPMC-Si were studied. It is shown that although silanization reduces the hydrodynamic volume in dilute solution, it does not affect significantly the rheological behavior of the concentrated solutions. The HPMC-Si viscous solution (pH 12.8) cross-links by decreasing the pH using an acid buffer, since HPMC-Si solution transforms into an elastic state. The kinetics of cross-linking and final elastic properties is influenced by several parameters such as polymer concentration, pH and temperature. pH and temperature play an important role in the silanol condensation, mainly responsible for network formation. The study of the gelation process revealed the dependence of the final concentration of HPMC-Si hydrogel on cross-linking kinetics and viscoelastic properties. The percolation theory was applied to determine gel point and to discuss the dependence of storage (G') and loss (G'') moduli on frequency. Results showed that both G' and G'' exhibit a power-law behavior with an exponent (0.68) which extends over the entire frequency range. This method is the only one to characterize the time where a liquid viscous phase shifts to hydrogel with elastic properties. In this case it was about 23 min for a final pH of 7.4

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Section: ] ′mentioning

confidence: 74%

Section: Icpcs Was Developedmentioning

confidence: 99%

Section: Icpcs Was Developedmentioning

confidence: 99%

Section: Synthesis Of Hpmc-simentioning

confidence: 99%

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The rheological properties of silated hydroxypropylmethylcellulose tissue engineering matrices

et al. 2008

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“…In an analogous manner to CMC, other cellulose ethers or esters have been used as a basis for forming hydrogels, either alone or in combination with other polymers (Harsh and Gehrke 1991;Oppermann 1995;Kabra et al 1998;Bourges et al 2002;Wach et al 2002;Lionetto et al 2003;Demitri et al 2008;Joshi et al 2008;Dai and Kadla 2009;Bao et al 2012). Bao et al (2012) observed higher absorbency in superabsorbents made from graft copolymers of CMC, in comparison with graft copolymers from hydroxypropyl methyl cellulose, methyl cellulose, and hydroxyethyl cellulose.…”

Section: Hydroxyethylcellulose (Hec) and Other Cellulose-derivative-bmentioning

confidence: 99%

Enhanced Absorbent Products Incorporating Cellulose and Its Derivatives: A Review

Hubbe¹,

Ayoub²,

Daystar³

et al. 2013

BioResources

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Cellulose and some cellulose derivatives can play vital roles in the enhancement of the performance of absorbent products. Cellulose itself, in the form of cellulosic fibers or nano-fibers, can provide structure, bulk, water-holding capacity, and channeling of fluids over a wide dimensional range. Likewise, cellulose derivatives such as carboxymethylcellulose (CMC) have been widely studied as components in superabsorbent polymer (SAP) formulations. The present review focuses on strategies and mechanisms in which inclusion of cellulose -in its various formscan enhance either the capacity or the rate of aqueous fluid absorption in various potential applications.

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Sol–Gel Synthesis of Solids

Coradin

2004

Encyclopedia of Inorganic and Bioinorganic Chemistry

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The synthesis of glasses and ceramics via the sol–gel route is based on the inorganic polymerization of molecular precursors such as metal alkoxides. Precursor structure and reactivity can be chemically controlled via complexation or acid–base catalysis. Sol–gel chemistry allows the powderless processing of glasses and ceramics, at much lower temperatures than that at usual solid‐state reactions. It provides a convenient and flexible access to nanoparticles, films, and fibers. Moreover, precursors are mixed at the molecular level and multicomponent materials can be formed. Thus, hybrid organic–inorganic materials have been made via the sol–gel route. The organic component can be used as a network modifier during the sol–gel synthesis and then withdrawn, allowing the formation of structured porous materials. It can also remain entrapped in the mineral matrix via weak interactions. Alternatively, organoalkoxysilanes allow covalent binding of organic moieties to silica networks. Such composites fill the gap between polymers and glasses, opening new possibilities for the design of functional materials in the fast developing areas of energy, biotechnology, and medicine.

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Synthesis and general properties of silated-hydroxypropyl methylcellulose in prospect of biomedical use

Cited by 111 publications

References 26 publications

The rheological properties of silated hydroxypropylmethylcellulose tissue engineering matrices

The rheological properties of silated hydroxypropylmethylcellulose tissue engineering matrices

Enhanced Absorbent Products Incorporating Cellulose and Its Derivatives: A Review

Sol–Gel Synthesis of Solids

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