Synthesis and Functionalization of Imidazo[1,2‐b]Pyridazine by Means of Metal‐Catalyzed Cross‐Coupling Reactions

Abstract

This review surveys the recent developments in organometallic-chemistry-based methods for the preparation of imidazo [1,2-b]pyridazines by cyclization as well as their functionalization by means of cross-coupling reactions such as Sonogashira, Heck, Negishi, Suzuki-Miyaura, Kumada and Stille. In addition, the advances made on the CÀ H activation of imidazo[1,2-b] pyridazines using C-arylation, C-benzylation and C-alkylation are also reviewed. Furthermore, the recent reports on the Narylation of this heterocyclic system are discussed and highlighted. The sequential couplings as well as the one-pot functionalization of two different positions on the imidazo[1,2b]pyridazine systems are also reviewed. Procedures in which metal-based catalysis is not involved in the functionalization of imidazo [1,2-b]pyridazines are not included in this review.(MTCC 3382), Staphylococcus aureus (MTCC 3160), Bacillus subtilis (MTCC 297), and Gram-negative bacteria: Pseudomonas aeruginosa (MTCC 1034), Klebsiella pneumoniae (MTCC).

Exploring the untapped pharmacological potential of imidazopyridazines

“…11,12 In recent years, transitionmetal catalysed synthetic routes to access imidazo[1,2-b]pyridazine derivatives from appropriate starting materials are increasingly being employed with established cross-coupling reactions. 13 In this copper catalysed reaction are extensively developed using catalyst with acetylacetonate, hexa-uoroacetylacetonate and triate ligands. This is followed by palladium-based metal catalyst and some other metal catalyst based on tin and gold are also reported.…”