Direct intermolecular C–H arylation of 6‐chloroimidazo[1,2‐b]pyridazine in its 3‐position was achieved, and the tolerance to reaction conditions in the presence of chloro groups was investigated. Various 3‐(hetero)arylimidazo[1,2‐b]pyridazines were synthesized in good to excellent yields. This methodology was successfully applied to the synthesis of 3,6‐di‐ and 2,3,6‐trisubstituted imidazo[1,2‐b]pyridazines by a microwave‐assisted, one‐pot, two‐step Suzuki cross‐coupling/palladium‐catalysed arylation process.
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