Synthesis and Fluorescent Property of Pyrazoline Derivatives

Abstract

A series of fluorinated pyrazoline derivatives were synthesized by the reaction of fluorinated chalcone with hydrazine ArNHNH2 (Ar=4‐BrC6F4, 4‐ClC6H4, C6H5, 4‐CH3C6H4 and 4‐CH3OC6H4). The structures of all these compounds were fully supported by their spectroscopic data and one of products was further confirmed by X‐ray single crystal diffraction analysis. The capability of fluorinated triaryl‐2‐pyrazolines to detect metal cations was investigated, by monitoring changes in their fluorescence spectra in the presence of Cd2+, Co2+, Cu2+, Mn2+, Ni2+ and Zn2+.

A Review on Metal Ion Sensors Derived from Chalcone Precursor

“…Encouraged by the need for the simple and reactive copper sensor for quick detection, Lu et al reported the pyrazoline-based chemosensor 5 (Fig. 3a) [51]. This pyrazoline-based chemosensor detected the copper ion with an enhancement of fluorescence intensity in the solvent mixture ethanol: water (1:7) at pH = 7.…”

3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

“…Generally, these compounds are prepared from substituted acetophenones and benzaldehydes via two-step reactions. The first is the synthesis of fluorinated chalcone through Claisen-Schmidt condensation, then the second is the synthesis of fluorinated pyrazoline through intermolecular cyclization of fluorinated chalcone with a hydrazine or its derivatives [7] such as thiosemicarbazide [4], phenylhydrazine [8], hydrazine hydrate [9], halogenated phenylhydrazine [10], and 3,4,5-trimethoxybenzohydrazide [11]. Other researchers have also reported one-pot synthesis of pyrazolines from various starting materials and methods such as from 3-butynol and substituted phenylhydrazine under reflux condition [12], from substituted acetophenone, benzaldehyde, and phenylhydrazine under reflux condition [13,14] and through the formal [4 + 1] annulation reaction of 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes by stirring at room temperature [15].…”

A study on enhancing the quantum yield and antimicrobial activity of Pr(iii) by varying the coordination environment

“…These two properties of Pr(III) complexes can be tuned to give an important application in the medicinal eld of tracing drugs. There are already a number of papers in the literature which present the luminescence behavior of the pyrazoline ligand itself, [38][39][40][41][42][43][44][45][46] and therefore, this study is important as it describes the effect of various ligands on the quantum yield of Pr. The luminescence behavior of these complexes was expected to change by varying ligands around the central metal ion.…”