Synthesis and fabrication of novel quinone-based chromenopyrazole antioxidant-laden silk fibroin nanofibers scaffold for tissue engineering applications

Kandhasamy, Subramani; Arthi, N.; Arun, Raj Pranap; Verma, Rama Shanker

doi:10.1016/j.msec.2019.04.076

Cited by 34 publications

(18 citation statements)

References 54 publications

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“…In addition to NPs, various of nano structures have been reported to remove ROS, such as nanosheet [ [108] , [109] , [110] ], nanorod [ 111 , 112 ], nanotube [ 113 , 114 ], nanofiber [ 115 , 116 ], and nanomesoporous [ 117 ], have been reported to remove ROS. These nanostructures have many active sites, large specific surface areas, or a specific structural effect, thus improving their ROS-scavenging effect.…”

Section: Ros-scavenging Nanomaterials That Promote Oxidative Damage Repair and Mechanisms Governing This Repairmentioning

confidence: 99%

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Huang

Zheng

et al. 2021

Materials Today Bio

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Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that are currently available. The good news is that owing to the considerable advances in nanoscience, multiple types of nanomaterials with unique ROS-scavenging abilities that influence the temporospatial dynamic behaviors of ROS in biological systems have been developed. This has led to the emergence of next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related inflammatory conditions. Accordingly, herein we reviewed recent progress in research on nanotherapy based on ROS scavenging. The underlying mechanisms of the employed nanomaterials are emphasized. Furthermore, important issues in developing cross-disciplinary nanomedicine-based strategies for ROS-based inflammatory conditions are discussed. Our review of this increasing interdisciplinary field will benefit ongoing studies and clinical applications of nanomedicine based on ROS scavenging.

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Section: Ros-scavenging Nanomaterials That Promote Oxidative Damage Repair and Mechanisms Governing This Repairmentioning

confidence: 99%

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Huang

Zheng

et al. 2021

Materials Today Bio

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“…PLOS ONE •Sponges w/carboxymethyl chitosan and collagen peptides [167] •Gold nanoparticles (AuNP) [168] •Stromal vascular fraction (SVF) [169] •Quinone-based chromenopyrazole (QCP) antioxidant-laden silk fibroin electrospun nanofiber scaffold [170] •Pulmonary fibrosis associated RNA overexpression [171] •Titanium dioxide nanoparticle biofilm [172] •Neonatal cardiac fibroblasts infected with ETV2 [173] •exosomes platelet rich plasma [174] •tonsil derived Stem cell media [175] • [176] •Elaidic and linoleic (fatty acids) [119] •Light exposure [177] •Primary rat alveolar macrophages (AMO)-derived monocyte chemotactic protein-induced protein 1 (MCPIP1) knockdown [178] •Oxymatrine and Notch signaling pathway inhibitor (DAPT) via TGF-β1 [161]…”

Section: Drugsmentioning

confidence: 99%

Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing

et al. 2021

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The scratch assay is an in vitro technique used to analyze cell migration, proliferation, and cell-to-cell interaction. In the assay, cells are grown to confluence and then ‘scratched’ with a sterile instrument. For the cells in the leading edge, the resulting polarity induces migration and proliferation in attempt to ‘heal’ the modeled wound. Keloid scars are known to have an accelerated wound closure phenotype in the scratch assay, representing an overactivation of wound healing. We performed a qualitative review of the recent literature searching for inhibitors of scratch assay activity that were already available in topical formulations under the hypothesis that such compounds may offer therapeutic potential in keloid treatment. Although several shortcomings in the scratch assay literature were identified, caffeine and allicin successfully inhibited the scratch assay closure and inflammatory abnormalities in the commercially available keloid fibroblast cell line. Caffeine and allicin also impacted ATP production in keloid cells, most notably with inhibition of non-mitochondrial oxygen consumption. The traditional Chinese medicine, shikonin, was also successful in inhibiting scratch closure but displayed less dramatic impacts on metabolism. Together, our results partially summarize the strengths and limitations of current scratch assay literature and suggest clinical assessment of the therapeutic potential for these identified compounds against keloid scars may be warranted.

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“…[76][77] Encouraged by these results, we tried conducting this reaction scheme using BDCBs 19 and 20 aiming at higher acenes. Thus, the cycloaddition reaction of either BDCB 19 or 20 with benzoquinone (25) was carried out under conventional heating as well as under microwave irradiation conditions and was anticipated to finally yield pentacene-1,4,9,12-tetraone (33). A careful chromatographic separation of the crude product afforded different fractions.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

“…[13][14][15][16][17] In addition, quinone structures are widely abundant in redox-active natural compounds associated with a number of biological processes like photosynthesis in plants and bacteria, [18][19][20] coenzyme Q functions, [21][22][23][24] vitamins K [25][26][27][28][29] and E [30][31][32] activities. They show marked anti-oxidant, [33][34] anti-inflammatory, [35][36][37] antibiotic, [38][39][40][41] and antitumoral [42][43][44][45] activities as well. Some FDA-approved quinone drugs are depicted in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Bidirectional Synthesis, Photophysical and Electrochemical Characterization of Polycyclic Quinones Using Benzocyclobutenes and Benzodicyclobutenes as Precursors

2021

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In Memory of Professor Klaus HafnerQuinones have widespread applications in view of their interesting chemical and photophysical features. On the other hand, benzocyclobutenes (BCBs) are generally masked reactive dienes suitable for the [4 + 2] cycloaddition reactions. Here, benzocyclobutenes and benzodicyclobutenes (BDCBs) were prepared and further reacted with benzoquinone and naphthoquinone in order to obtain some new polycyclic quinones with highly extended π systems, namely, 6-bromo-5,8-dimeth-

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Synthesis and fabrication of novel quinone-based chromenopyrazole antioxidant-laden silk fibroin nanofibers scaffold for tissue engineering applications

Cited by 34 publications

References 54 publications

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing

Bidirectional Synthesis, Photophysical and Electrochemical Characterization of Polycyclic Quinones Using Benzocyclobutenes and Benzodicyclobutenes as Precursors

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