We report the discovery in TESS Sectors 3 and 4 of a compact triply eclipsing triple star system. TIC 209409435 is a previously unknown eclipsing binary with a period of 5.717 d, and the presence of a third star in an outer eccentric orbit of 121.872-d period was found from two sets of third-body eclipses and from eclipse timing variations. The latter exhibits signatures of strong third-body perturbations. After the discovery, we obtained follow-up ground-based photometric observations of several binary eclipses as well as another of the third-body eclipses. We carried out comprehensive analyses, including the simultaneous photodynamical modelling of TESS and ground-based light curves (including both archival WASP data, and our own follow-up measurements), as well as eclipse timing variation curves. Also, we have included in the simultaneous fits multiple star spectral energy distribution data and theoretical PARSEC stellar isochrones. We find that the inner binary consists of near twin stars of mass 0.90 M⊙ and radius 0.88 R⊙. The third star is just 9 per cent more massive and 18 per cent larger in radius. The inner binary has a rather small eccentricity, while the outer orbit has e = 0.40. The inner binary and outer orbit have inclination angles within 0.1° and 0.2° of 90°, respectively. The mutual inclination angle is ≲1/4°. All of these results were obtained without radial velocity observations.

Chitosan-coated ceria nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation with powerful anti-inflammation and anti-oxidation properties.

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that are currently available. The good news is that owing to the considerable advances in nanoscience, multiple types of nanomaterials with unique ROS-scavenging abilities that influence the temporospatial dynamic behaviors of ROS in biological systems have been developed. This has led to the emergence of next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related inflammatory conditions. Accordingly, herein we reviewed recent progress in research on nanotherapy based on ROS scavenging. The underlying mechanisms of the employed nanomaterials are emphasized. Furthermore, important issues in developing cross-disciplinary nanomedicine-based strategies for ROS-based inflammatory conditions are discussed. Our review of this increasing interdisciplinary field will benefit ongoing studies and clinical applications of nanomedicine based on ROS scavenging.

We use imaging polarimetry taken with the HST Advanced Camera for Surveys High Resolution Camera to explore the three-dimensional structure of the circumstellar dust distribution around the red supergiant VY Canis Majoris. The polarization vectors of the nebulosity surrounding VY CMa show a strong centrosymmetric pattern in all directions except directly east and range from 10% to 80% in fractional polarization. In regions that are optically thin, and therefore likely to have only single scattering, we use the fractional polarization and photometric color to locate the physical position of the dust along the line of sight. Most of the individual arclike features and clumps seen in the intensity image are also features in the fractional polarization map. These features must be distinct geometric objects. If they were just local density enhancements, the fractional polarization would not change so abruptly at the edge of the feature. The location of these features in the ejecta of VY CMa using polarimetry provides a determination of their three-dimensional geometry independent of, but in close agreement with, the results from our study of their kinematics (Paper I).

Background: Non-communicable chronic diseases (NCDs) have become the top threat in China. This study aimed to estimate the prevalence of major NCDs among the elderly population in rural areas in southern China and explore its associated social determinants. Methods: A multistage cluster random sampling methodology was adopted to select a total of 9245 rural elderly people from 3860 rural households in Guangdong Province. Interviews and physical examinations were performed to collect patient information. Descriptive and logistic regression analyses were conducted to explore factors associated with the presence of major NCDs. Results: Over one-third (38.5%) of the study population suffered from five major NCDs. The grade of activities of daily living (ADL), mental status, and social relationship of elderly people without NCDs were better than those with NCDs. The major factors associated with the presence of NCDs among the elderly people included age (70–79 years group and 80–89 years group), education level (senior high/technical secondary school and junior college and above), mental status (concentration, enrichment and happy life and memory), relationship with neighbours, activities of daily living (ADL) (being able to climb three floors and bend over), physical activity, marital status (bereft), and living conditions (with offspring and family members). Conclusions: The study identified several social determinants associated with the presence of major NCDs. A higher level of family support and physical exercise might contribute to improved physical condition, mental status, and ADL among the elderly people in rural areas in southern China.

Water-soluble CdS nanocrystals (NCs) capped with mercaptoacetic acid (MA) were synthesized in aqueous solution. Hydrogen peroxide directly oxidized the MA-capped CdS NCs and produced strong chemiluminescence (CL) emission in basic conditions. It was found that the CL of CdS NCs was size-dependent, and the CL intensity increased with increasing CdS NCs size. UV–visible spectra, CL spectra, photoluminescence (PL) spectra, and transmission electron microscopy (TEM) were used to investigate the CL reaction mechanism. Moreover, the effects of reactant concentrations, surfactants, and some biological molecules and metal ions were carefully investigated. Some biological molecules and metal ions were observed to inhibit the CL signal of the H2O2–CdS NCs system, which makes it applicable for the detection of such species.

No abstract

To our knowledge, this is the first report that l-serine can potentiate the action of ofloxacin or moxifloxacin against Gram-negative bacteria and could constitute a new strategy for the eradication of bacterial infections.