Synthesis and Evaluation the Activity of 1, 3, 4-Thiadiazole Derivatives as Antibacterial Agent Against Common Pathogenic Bacteria

Abstract

Schiff base compound 5-(benzylideneamino)-1,3,4-thiadiazole-2-thiol was prepared from condensation reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with benzaldehyde. Schiff bases react with Copper(ӀӀ), Ferric(ӀӀӀ), Cobalt(ӀӀ) and Zinc(ӀӀ) to form four complexes. The Schiff base complexes were identification by using FTIR and UV-VIS. The antibacterial activity of complexes (Copper(ӀӀ), Ferric(ӀӀӀ), Cobalt(ӀӀ) and Zinc(ӀӀ)) were studied against S. aureus and S. epidermidis as a model of Gram positive, E. coli, P. mirabilis, C. freundii and P. aeruginosa as a Gram negative model to determine activity of synthesized complexes, after subjected them to some tests to confirm the identity of the pathogenic bacteria. Ten antibiotics (Ampicillin and Amoxicillin) have been chosen to investigate the ability of bacterial isolates to resistant the conventional antibiotic. Imipenem have been selected to contrast its efficiency with those of the new compounds because of its high efficiency. The results exhibited higher activity of the new compounds proportional to the chosen antibiotics.

Preparation of New Series of Tetradentate Schiff Base Complexes and Studing Them Spectroscopically, Biologically and Theoretically

“…Also bands appeared at (22557,33557) cm -1 which due to IL → CoCT sequentially) (Akram & Daham, 2019). The color yellow of NiL complex, also the bands appeared at (10812, 15877) cm -1 is assigned to 3 A 2 g→ 3 T 2 g, 3 ). In the cupper black complex the broadness band in spectrum is attributed to ²Eg →²T 2 g. The magnetic moment for the Cu(II) complex are 1.78 BM.…”

Design, synthesis, spectral analysis, and biological evaluation of Schiff bases with a 1,3,4-thiadiazole moiety as an effective inhibitor against bacterial and fungal strains

“…When 1,3,4-thiadiazole containing 1,3,4oxadiazole derivatives was synthesized, many pathogenic bacterial strains were isolated from patients, including Streptococcus, Acinetobacter, E. coli, Klebsiella, Staphylococcus, and Aeromonas, showed increased to moderate antibacterial activity [44]. The antibacterial activity of the complexes (Cu, Fe, Co and Zn) was investigated against S. aureus and S. epidermidis as Gram-positive bacteria, and E. coli, P. mirabilis, C. freundii and P. aeruginosa as Gram-negative bacteria to determine the activity of the synthesized complexes, and the results exhibited higher activity [45].…”

Determination of Antioxidants and Antimicrobial Activities of Platytaenia multicaule

“…It has various forms because of the capability to undergo through the tautomerism process. 1,3,4-thiadiazol shows antifungal and antibacterial activities [25]. It is distributed in Balochistan province especially in District Ziarat at various locations such as village Spazandi, Sarbara Tangi and Kharvari Baba.…”