Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging β-amyloid in Alzheimer’s disease

Zeng, Fanxing; Southerland, Jeanine A.; Voll, Ronald J.; Votaw, John R.; Williams, Lawrence R.; Ciliax, Brian J.; Levey, Aĺlan I.; Goodman, Mark M.

doi:10.1016/j.bmcl.2006.02.055

Cited by 48 publications

(25 citation statements)

References 16 publications

(9 reference statements)

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“…The two age ranges were similarly represented. These monkeys survive in captivity approximately 25 to 35 years or about a quarter to a third of the life span of humans (Kaufman et al 2005;Rao et al 1998;Weigl 2005;Freimer et al 2007;Fears et al 2009;Oikawa et al 2010). Therefore, the young adult group averaging 9 years of age approximates humans that are about 30 years of age, whereas the old adult group, averaging 20 years of age, approximates humans of about 70 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…Central fat deposition patterns are associated with social stress as well as carotid and coronary artery atherosclerosis in cynomolgus monkeys and with cardiovascular disease in people (Shively et al 2009). Finally, Old World monkeys are optimal models for investigations involving cognitive decline and Alzheimer's disease due to their similarities to humans in central nervous system mobility (Gallagher and Rapp 1997;Voytko and Tinkler 2004;Kulstad et al 2005;Zeng et al 2006). Thus, Old World monkeys are useful Fig.…”

Section: Discussionmentioning

confidence: 99%

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Aging and physical mobility in group-housed Old World monkeys

Shively

Willard

et al. 2011

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While indices of physical mobility such as gait speed are significant predictors of future morbidity/ mortality in the elderly, mechanisms of these relationships are not understood. Relevant animal models of aging and physical mobility are needed to study these relationships. The goal of this study was to develop measures of physical mobility including activity levels and gait speed in Old World monkeys which vary with age in adults. Locomotor behaviors of 21 old (x0 20 yoa) and 24 young (x09 yoa) socially housed adult females of three species were recorded using focal sample and ad libitum behavior observation methods. Selfmotivated walking speed was 17% slower in older than younger adults. Likewise, young adults climbed more frequently than older adults. Leaping and jumping were more common, on average, in young adults, but this difference did not reach significance. Overall activity levels did not vary significantly by age, and there were no significant age by species interactions in any of these behaviors. Of all the behaviors evaluated, walking speed measured in a simple and inexpensive manner appeared most sensitive to age and has the added feature of being least affected by differences in housing characteristics. Thus, walking speed may be a useful indicator of decline in physical mobility in nonhuman primate models of aging.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Aging and physical mobility in group-housed Old World monkeys

Shively

Willard

et al. 2011

AGE

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“…164-165°C. 1 Supporting Information (see footnote on the first page of this article): Crystal structures of 3a and 5,…”

Section: Preparation Of 10-[3-oxo-14-diphenyldibenzo[fh]isoquinolinmentioning

confidence: 99%

“…As a significant family of nitrogen-containing heterocycles, imidazo [1,2-a]pyridines have attracted much attention in recent years owing to their interesting biological and medical activities, [1][2][3][4] especially antiviral, [5] antitubercular [6] and antimicrobial activities. [7] Moreover, a series of novel 21 compounds based on a central imidazo[1,2-a]pyridine scaffold that exhibit promising inhibitory potential towards kinases have been reported.…”

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confidence: 99%

9,11,12,14‐Tetraaryldibenzo[f,h]imidazo[1,2‐b]isoquinolines and Their Emission Responses to Solvent Polarity, Acidity, and Nitroarenes

et al. 2013

Eur J Org Chem

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9,11,12,14‐Tetraaryldibenzo[f,h]imidazo[1,2‐b]isoquinolines 3a–h were synthesized in moderate yields through the reaction of benzils with 1,3‐diphenyl‐2H‐cyclopenta[l]phenanthren‐2‐ones and ammonium acetate. The photophysical properties of the products in solutions and in thin films were investigated, and strong emissions ranging from 492 to 516 nm were observed in cyclohexane solutions. Moreover, 3h exhibited potential as a versatile fluorescent chemosensor for the detection of solvent polarity, acidity, or trace amounts of nitroaromatics.

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“…For early diagnosis or monitoring of β-amyloid formation and aggregation in AD brain, a variety of radiolabeled compounds as imaging probes have been developed. [17][18][19] The development of ligands specifically binding to β-amyloid aggregates is very important for labeling agents as in vivo diagnostic tools. Our continuous object has been to explore the novel ligands applicable to imaging probes with high binding affinity to Aβ fibrils.…”

Section: Introductionmentioning

confidence: 99%