Synthesis and evaluation of sucrose‐containing polymeric hydrogels for oral drug delivery

Abstract

Biodegradable and biocompatible copolymeric hydrogels based on sucrose acrylate, N-vinyl-2-pyrrolidinone, and acrylic acid were designed and synthesized. Because of the growing importance of sugar-based hydrogels as drug delivery systems, these new pH-responsive sucrose-containing copolymeric hydrogels were investigated for oral drug delivery. The sucrose acrylate monomer was synthesized and characterized. The copolymeric hydrogel was synthesized by free-radical polymerization. Azobisisobutyronitrile (AIBN) was the free-radical initiator employed and bismethyleneacrylamide (BIS) was the crosslinking agent used for hydrogel preparations. Homopolymeric vinyl pyrrolidone hydrogels were also prepared by the same technique. The hydrogels were characterized by differential scanning calorimetry, thermogravimetric analysis, and scanning electron microscopy. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). These results indicate the pH-responsive nature of the hydrogels. The gels swelled more in SIF than in SGF. A model drug, propranolol hydrochloride (PPH), was entrapped in these gels and the in vitro release profiles were established separately in both enzymefree SGF and enzyme-free SIF. The drug release was found to be faster in SIF. About 93 and 99% of the entrapped drug was released over a period of 24 h in SGF and SIF, respectively.

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

“…The synthetic polymers are hydrophobic, chemically stronger, and durable with a slow rate of degradation compared to natural polymers [101][102][103][104][105]. Hydrogels based on natural polymers have suitable functional groups or can be modified with free-radically polymerizable functional groups [106]. For example, the formulation of methacrylated gellan gum (GeGMA) has been suggested as a second-generation hydrogel for the repairing of cartilage tissues [107].…”

Biomedical applications of polymers 2001 - 2002

“…Bismethylenacrylamide was used as the crosslinking agent. Propanolol HCl (PPH) was entrapped, as a model drug, in the gels [101].…”

Amphiphilic copolymers of sucrose methacrylate and acrylic monomers: Bio-based materials from renewable resource

“…The combination of these monomers with hydrophobic ones (e.g., methyl methacrylate) can lead to amphiphilic copolymers with a wide range of properties and applications. Typically, amphiphilic polymers, such as sugar-based polymers, are widely used in applications that require biocompatibility and/or biodegradability (Barros, Petrova, & Singh, 2010;Cheng & Gross, 2010;Feng et al, 2010;Galgali, Puntambekar, Gokhale, & Varma, 2004;Miura, 2007;Patil et al, 1997;Shantha & Harding, 2002;Takasu, Baba, & Hirabayashi, 2008).…”