Synthesis and Evaluation of some New 5-Substituted-1,3,4- oxadiazol-2yl-4-(morpholin-4yl Sulfonyl)benzyl Sulfides as Antibacterial Agent

Abstract

Purpose: To synthesise a new series of 3,benzyl sulfide and evaluate their antibacterial activity. Methods: Different organic acids were converted consecutively into corresponding esters,3,. The targets, 6a-e were synthesized by stirring 4a-e with 4-(4-(bromomethyl) 11.01 ± 0.31, 15.37 ± 3.33, 16.11 ± 1.14, 9.70 ± 1.96, 10.01 ± 2.70 and 9.15 ± 0.29, respectively. However, none , S. typhi (-), E. coli (-), K. pneumoniae (-), P. aeruginosa (-), B. subtilis (+) and S. aureus (+) with MIC (μM) values of