Synthesis and Evaluation of Some 1,4‐Dihydropyridine and Their Derivatives as Antihypertensive Agents.

Abstract

The title compounds are tested for their antihypertensive activity. Derivatives (Vb), (Vc), and (Ve) show the maximum effects compared to the standard drug nifedipine. -(PATTAN*, S. R.; RASAL, V. P.; VENKATRAMANA, N. V.; KHADE, A. B.; BUTLE, S. R.; JADHAV, S. G.; DESAI, B. G.; MANVI, F. V.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 46 (2007) 4, 698-701; Dep. Med. Chem., Coll. Pharm.,

Microwave Mediated Synthesis and Analytical Method Development for the Estimation of Novel 1,4-Dihydropyridines in Bulk by RP-HPLC

“…Dihydropyridines (DHPs) have been reported to be the most frequently prescribed CCBs for the treatment of hypertension in many regions of eastern Asian countries including China [9,10]. The fascinating biological spectra of the calcium channel antagonists have led to the development of newer technologies to improve conventional methods of prepara-tion using various catalysts such as copper (II) triflate [11], molecular iodine [12], organocatalyst [13], trifluoroacetic acid [14]. Further to overcome inherited drawbacks of longer reaction times and poor yields, microwave assisted organic synthesis (MAOS) [15,16] has been adopted.…”

Synthesis and antimicrobial activity of a new series 1,4-dihydropyridine derivatives

“…7 Recently, it was reported that the amide group was involved in the 3,5-position of 1,4-dihydropyridine derivatives and it exhibited pharmacological effects. 8,9 Basically thiosemicarbazone containing heterocyclics have significant biological activity, such as antitumour, fungicidal, bactericidal, antiinflammatory and antiviral activities. [10][11][12][13] In view of these observations, it was decided to synthesize a new series of 1,4-dihydropyridine derivatives (2a-g) and screen them for their level of antimicrobial activity.…”

Virtual Toxicity Studies of Novel 1,4-Dihydropyridine Derivatives

“…1,4-Dihydropyridines and pyrazolidine-3,5-diones have emerged as important classes of drugs for the treatment of variety of health conditions. These nuclei are common to numerous bioactive compounds which include antihypertensive, antitumor, vasodilator, antibacterial, anticonvulsant, anti-inflammatory, antidiabetic agents [1][2][3][4][5][6] . Drug design softwares like TOPKAT enables the discovery of lead molecules, more efficiently and quickly.…”