Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates

Boxus, Thierry; Touillaux, Roland; Dive, Georges; Marchand‐Brynaert, Jacqueline

doi:10.1016/s0968-0896(98)00083-2

Cited by 38 publications

(25 citation statements)

References 58 publications

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“…Longer, more specific sequences have higher affinities for activated platelets than the GRGDS peptide. However, the length of the peptide can have dramatic effects on its temperature stability (26) as well as production costs. We designed these synthetic platelets to be stable at room temperature to facilitate their potential administration in the field.…”

Section: Discussionmentioning

confidence: 99%

Intravenous Hemostat: Nanotechnology to Halt Bleeding

et al. 2009

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Blood loss is the major cause of death in both civilian and battlefield traumas. Methods to staunch bleeding include pressure dressings and absorbent materials. For example, Quik-clot effectively halts bleeding by absorbing large quantities of fluid and concentrating platelets to augment clotting, but these treatments are limited to compressible and exposed wounds. An ideal treatment would halt bleeding only at the injury site, be stable at room temperature, be administered easily, and work effectively for internal injuries. We have developed synthetic platelets, based on ArgGly-Asp functionalized nanoparticles, that halve bleeding time after intravenous administration in a rat model of major trauma. The effects of these synthetic platelets surpass other treatments including recombinant factor VIIa, which is used clinically for uncontrolled bleeding. Synthetic platelets were cleared within 24 hours at a dose of 20 mg/ml, and no complications were seen out to 7 days after infusion, the longest time point studied. These synthetic platelets may be useful for early intervention in trauma and demonstrate the role that nanotechnology can have in addressing unmet medical needs.

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Section: Discussionmentioning

confidence: 99%

Intravenous Hemostat: Nanotechnology to Halt Bleeding

et al. 2009

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“…Covalent immobilization of RGD peptides / small protein fragments on polymeric surfaces is another approach for surface modification of polymers [65,77]. Some of the studies that have applied this approach include covalent immobilization of RGD peptides on polystyrene surfaces with the help of polyethylene oxide [40], RGD peptidemodified poly(lactic acid-co-lysine) (PLAL) wherein, the RGD peptide was chemically cross-liked with lysine residue of PLAL with the help of 1,1-carbonyl diimidazole [78], and covalent immobilization of RGD peptides, collagen and fibronectin protein on polyvinyl alcohol surfaces [79][80][81].…”

Section: B Chemical Modificationmentioning

confidence: 99%

Improved Biomaterials for Tissue Engineering Applications: Surface Modification of Polymers

Katti

Vasita

Shanmugam³

2008

CTMC

186

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Tissue engineering approaches that combine biomaterial-based scaffolds with protein delivery systems have provided a potential strategy for improved regeneration of damaged tissue. The success of polymeric scaffolds is determined by the response it elicits from the surrounding biological environment. This response is governed, to a large extent, by the surface properties of the scaffold. Surfaces of polymeric scaffolds have a significant effect on protein and cell attachment. Multiple approaches have been developed to provide micrometer to nanometer scale alterations in surface architecture of scaffolds to enable improved protein and cell interactions. Chemical modification of polymeric scaffold surfaces is one of the upcoming approaches that enables enhanced biocompatibility while providing a delivery vehicle for proteins. Similarly, physical adsorption, radiation mediated modifications, grafting, and protein modifications are other methods that have been employed successfully for alterations of surface properties of polymeric scaffolds. The goal of this review is to provide an overview of the role of surface properties /chemistry in tissue engineering and briefly discuss some of the methods of surface modification that can provide improved cell and protein interactions. It is hoped that these improved polymeric scaffolds will lead to accelerated and functional tissue regeneration.

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“…La majorité des problèmes discutés ci-dessus peuvent être abolis en utilisant des petits peptides contenant les motifs de reconnaissance cellulaire. Ceux-ci exhibent une plus grande stabilité au niveau des conditions de stérilisation [43], des variations de pH [48], des expositions à la chaleur, ils présentent également des facilités de stockage [49], sont plus faciles à caractériser et sont d'un moindre coût. Compte tenu du faible encombrement des peptides, ceux-ci peuvent être fixés avec une plus haute densité en surface ce qui peut compenser une éventuelle activité d'adhésion cellulaire affaiblie.…”

Section: Protéines Ou Peptides ?unclassified

Conception, élaboration et caractérisation de matériaux bioactifs

Durrieu

2005

ITBM-RBM

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Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates

Cited by 38 publications

References 58 publications

Intravenous Hemostat: Nanotechnology to Halt Bleeding

Intravenous Hemostat: Nanotechnology to Halt Bleeding

Improved Biomaterials for Tissue Engineering Applications: Surface Modification of Polymers

Conception, élaboration et caractérisation de matériaux bioactifs

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