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AbstractÐSeveral RGD peptidomimetics have been prepared, in a convergent way, from the common ortho-aminotyrosine template (O-substituted with an anchorage-arm or a methyl group, and aN-substituted with a¯uorine tag for XPS analysis), and various o-aminoacid derivatives. The most¯exible compounds have shown a biological activity similar to that of the peptide reference (RGDS) in the platelet aggregation test. The compound 16a could be ®tted (by modelisation) with DMP 728 and c(RGDfV), two cyclic peptides that are good ligands of integrins. The compound 16b has been covalently ®xed on the surface of a poly(ethylene terephthalate) membrane used as support for mammalian cell cultivation. #

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