2018
DOI: 10.1016/j.jddst.2017.10.010
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Synthesis and evaluation of pH dependent polyethylene glycol- co -acrylic acid hydrogels for controlled release of venlafaxine HCl

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Cited by 26 publications
(3 citation statements)
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“…The reduction in swelling capacity upon the addition of AAc to the formulation can be considered as a direct effect of inclusion of this specie in the chemically cross-linked polymer network. It is expected that the copolymerized acrylic acid makes the system more hydrophilic due to the ionization of carboxylate groups, which would result in higher water uptake. , In addition, carboxylate groups increase the osmotic pressure, which leads to higher swelling capacity . Therefore, the observed decrease in the swelling capacity of polyLLC with acrylic acid comonomer can be attributed to the increased cross-link density of the system, induced by enhanced reactive sites in the LLC precursor.…”
Section: Resultsmentioning
confidence: 99%
“…The reduction in swelling capacity upon the addition of AAc to the formulation can be considered as a direct effect of inclusion of this specie in the chemically cross-linked polymer network. It is expected that the copolymerized acrylic acid makes the system more hydrophilic due to the ionization of carboxylate groups, which would result in higher water uptake. , In addition, carboxylate groups increase the osmotic pressure, which leads to higher swelling capacity . Therefore, the observed decrease in the swelling capacity of polyLLC with acrylic acid comonomer can be attributed to the increased cross-link density of the system, induced by enhanced reactive sites in the LLC precursor.…”
Section: Resultsmentioning
confidence: 99%
“…When placed in water or other biological fluids, hydrogel has ability to resist disintegration [21][22][23][24][25]. For example, polyethylene glycol can be cross-linked to form hydrogel having stereographic polymeric constructions that can suck up a huge amount of water which varies from few percent to hundreds of times in comparison to its dry weight [26][27][28][29]. The crosslinkage into various polymer chains is introduced with the help of a cross-linkage agent [30][31][32][33].…”
Section: Introductionmentioning
confidence: 99%
“…As one type of PEG-based material, the copoly(PEGDA/PEGA) hydrogel is suitable for biomolecule imprinting and environmentally friendly applications owing to its features such as low toxicity and bio-compatibility. On the other hand, prosperous studies are using PEG-based materials, including PEG materials with ideally controllable structure, 40 enhanced mechanical properties, 41,42 and responsiveness to narrow temperature zone, pH, 37,[43][44][45][46] ionic strength, 47 etc. Thus, it is worthy to study the PEG-based MIPs to promote the diversity of MIP materials.…”
Section: Introductionmentioning
confidence: 99%