Synthesis and evaluation of pH dependent polyethylene glycol- co -acrylic acid hydrogels for controlled release of venlafaxine HCl

Ijaz, Qazi Amir; Abbas, Nasir; Arshad, Muhammad Sohail; Hussain, Amjad; Shahiq-uz-Zaman,; Javaid, Zeeshan

doi:10.1016/j.jddst.2017.10.010

Cited by 26 publications

(3 citation statements)

References 27 publications

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“…The reduction in swelling capacity upon the addition of AAc to the formulation can be considered as a direct effect of inclusion of this specie in the chemically cross-linked polymer network. It is expected that the copolymerized acrylic acid makes the system more hydrophilic due to the ionization of carboxylate groups, which would result in higher water uptake. , In addition, carboxylate groups increase the osmotic pressure, which leads to higher swelling capacity . Therefore, the observed decrease in the swelling capacity of polyLLC with acrylic acid comonomer can be attributed to the increased cross-link density of the system, induced by enhanced reactive sites in the LLC precursor.…”

Section: Resultsmentioning

confidence: 99%

Self-Assembled Nanofiltration Membranes with Thermo- and pH-Responsive Behavior

Saadat,

Tabatabaei,

Kim

et al. 2024

ACS EST Eng.

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We produce controlled nanostructured membranes from cross-linking of self-assembled diacrylated poloxamers. At sufficiently high concentrations, poloxamers form lyotropic liquid crystals (LLCs), such as lamellar (L α), cubic packing of spherical micelles, and hexagonal packing of rod-like micelles in water (H1). We use the H1 phase as a template to produce orderly packed nanofibrous membranes. The obtained membrane has a continuous 3D transport pathway and can alter its nanofiltration (NF) properties in response to changes in temperature and pH. The formulation includes Pluronic P84-diacrylate (P84DA), a thermoresponsive component that acts as both macromer and structure-directing amphiphile. P84DA facilitates changes in membrane pore size with temperature due to its thermoresponsiveness when it is in contact with water. Furthermore, the precursor contains acrylic acid (AAc) as the charged component, which upon copolymerization with P84DA, not only enables ion separation through Donnan exclusion but also imparts pH-responsive behavior for the separation of ionic species. The membrane performance is studied and compared with a commercial NF membrane (NF270). We show that the synthesized NF membrane has separation properties adjustable with temperature and pH with exceptional resistance to fouling by various solutes due to its highly hydrophilic surface. Furthermore, the membrane shows an outstanding sulfate over chloride ion selectivity, which is a requirement for salt fractionation applications. Deducted from separate experiments, the ideal chloride/sulfate selectivity for magnesium cation is about 2.38 at low ionic strengths. This study is done on a model system to show the capability of incorporating pH-responsiveness in LLC templated membranes, in which the pH-responsive range can be designed by changing the charged groups of comonomer in the formulation.

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Section: Resultsmentioning

confidence: 99%

Self-Assembled Nanofiltration Membranes with Thermo- and pH-Responsive Behavior

Saadat,

Tabatabaei,

Kim

et al. 2024

ACS EST Eng.

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“…When placed in water or other biological fluids, hydrogel has ability to resist disintegration [21][22][23][24][25]. For example, polyethylene glycol can be cross-linked to form hydrogel having stereographic polymeric constructions that can suck up a huge amount of water which varies from few percent to hundreds of times in comparison to its dry weight [26][27][28][29]. The crosslinkage into various polymer chains is introduced with the help of a cross-linkage agent [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Cellulosic biomass-based sustainable hydrogels for wastewater remediation: Chemistry and prospective

Thakur

Verma

Kumar

et al. 2022

Fuel

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“…As one type of PEG-based material, the copoly(PEGDA/PEGA) hydrogel is suitable for biomolecule imprinting and environmentally friendly applications owing to its features such as low toxicity and bio-compatibility. On the other hand, prosperous studies are using PEG-based materials, including PEG materials with ideally controllable structure, 40 enhanced mechanical properties, 41,42 and responsiveness to narrow temperature zone, pH, 37,[43][44][45][46] ionic strength, 47 etc. Thus, it is worthy to study the PEG-based MIPs to promote the diversity of MIP materials.…”

Section: Introductionmentioning

confidence: 99%