Specific recognition of a target protein, cytochrome <i>c</i>, using molecularly imprinted hydrogels

Liu, Chenchen; Kubo, Takuya; Otsuka, Koji

doi:10.1039/d2tb00501h

J. Mater. Chem. B

2022

DOI: 10.1039/d2tb00501h

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Specific recognition of a target protein, cytochrome c, using molecularly imprinted hydrogels

Chenchen Liu

Takuya Kubo

Koji Otsuka

Abstract: Protein imprinted hydrogel, which is one form of protein imprinted molecularly imprinted polymers (MIPs), is an important material for enzyme-linked immunosorbent assay, drug delivery materials, sensors, separation materials, etc. To...

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Cited by 6 publications

References 54 publications

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Advances in the selection of functional monomers for molecularly imprinted polymers: A review

Niu,

Du,

et al. 2024

J of Separation Science

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Molecularly imprinted polymers, a type of special polymer materials, are widely used in biosensing and other fields due to their ability to specifically recognize target molecules, often called “artificial receptors.”. Nowadays, researchers are constantly exploring new design and synthesis methods for molecularly imprinted materials to improve the selectivity and sensitivity of molecularly imprinted materials. Among them, the selection of functional monomers has attracted great attention. This review comprehensively analyzes and discusses the selection methods of functional monomers. The most commonly used functional monomers among different types of templates are screened based on the structural properties of the template molecules, including the selection of functional monomers among ion‐imprinted polymers, protein‐imprinted polymers, and bacterial imprinted polymers. The rich binding sites and functional group types of multifunctional monomers are also highlighted to advance the development of molecular imprinting technology. The article further explores the current challenges and prospects in the selection of functional monomers and emphasizes multiplex experiments and computer simulations as important directions for future research. This review provides comprehensive information and constructive guidelines for researchers in selecting functional monomers in areas such as analytical chemistry and biosensors.

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Advances in the selection of functional monomers for molecularly imprinted polymers: A review

Niu,

Du,

et al. 2024

J of Separation Science

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Sequentially Controlled Recognition of Different Proteins Using Programmable Protein Imprinted Nanospheres

Wang

Zhang

et al. 2023

Small

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Although protein imprinted materials with multiple templates are developed to selectively separate different proteins, it is difficult to achieve the programmed adsorption and separation of different proteins using one material, because the available protein imprinted materials are constructed through irreversible crosslinking and their structures are unprogrammable and non‐reconstructive. Herein, a novel nanosphere (MS@PTL‐g‐PNIPAM) is designed, which not only is temperature and pH responsive but also can dynamically reversibly crosslink/de‐crosslink under ultraviolet light of different wavelengths. With the help of the dynamically reversible photo‐crosslinking, the nanospheres can be repeatedly programmed into protein imprinted nanospheres toward different target proteins. Moreover, the prepared imprinted nanospheres can easily achieve the controlled rebinding and release of target proteins, benefiting from the introduced temperature‐ and pH‐responsive moieties. As a consequence, this study realizes the specific separation of different target proteins from protein mixture and the real bovine blood sequentially by programming one material. It is resource saving, time saving, recyclable, and it will provide convenience for protein imprinted materials to use in the blood purification, drug delivery, and virus detection.

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Green and eco-friendly porous imprinted hydrogels with cellulose nanocrystals-based precise-designed hyperbranched sites for high-accuracy separation and purification of naringin

Liu,

Tang,

Huang

et al. 2024

Chemical Engineering Journal

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Specific recognition of a target protein, cytochrome c, using molecularly imprinted hydrogels

Abstract: Protein imprinted hydrogel, which is one form of protein imprinted molecularly imprinted polymers (MIPs), is an important material for enzyme-linked immunosorbent assay, drug delivery materials, sensors, separation materials, etc. To...

Cited by 6 publications

References 54 publications

Advances in the selection of functional monomers for molecularly imprinted polymers: A review

Advances in the selection of functional monomers for molecularly imprinted polymers: A review

Sequentially Controlled Recognition of Different Proteins Using Programmable Protein Imprinted Nanospheres

Green and eco-friendly porous imprinted hydrogels with cellulose nanocrystals-based precise-designed hyperbranched sites for high-accuracy separation and purification of naringin

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