Synthesis and Evaluation of Isoflavones as Potential Anti-inflammatory Inhibitors

Ramaite, Isaiah D. I.; Maluleke, Musa D.; Mnyakeni-Moleele, Simon S.

doi:10.1007/s13369-017-2614-z

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Flavonol compounds, including kaempferol, quercetin, myricetin, and galangin, are plentiful in certain vegetables and fruits such as broccoli, onions, asparagus, and apples (Pinto et al, 2021). Isoflavones, characterized by a chemical structure based on the 3‐phenyl chromen‐4‐one backbone, typically accumulate in leguminous plants, with soy and soy‐derived products being primary sources (Ramaite et al, 2017). These phytoestrogens share structural similarities with estradiol‐17β and molecular resemblances to animal estrogens, serving as phytoestrogens.…”

Section: Polyphenol Compoundsmentioning

confidence: 99%

“…Isoflavones, characterized by a chemical structure based on the 3-phenyl chromen-4-one backbone, typically accumulate in leguminous plants, with soy and soy-derived products being primary sources (Ramaite et al, 2017). These phytoestrogens share structural similarities with estradiol-17β and molecular resemblances to animal estrogens, serving as phytoestrogens.…”

Section: Polyphenol Compoundsmentioning

confidence: 99%

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Modulation of long noncoding RNAs by polyphenols as a novel potential therapeutic approach in lung cancer: A comprehensive review

Lv,

Qian,

et al. 2024

Phytotherapy Research

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Lung cancer stands as a formidable global health challenge, necessitating innovative therapeutic strategies. Polyphenols, bioactive compounds synthesized by plants, have garnered attention for their diverse health benefits, particularly in combating various cancers, including lung cancer. The advent of whole‐genome and transcriptome sequencing technologies has illuminated the pivotal roles of long noncoding RNAs (lncRNAs), operating at epigenetic, transcriptional, and posttranscriptional levels, in cancer progression. This review comprehensively explores the impact of polyphenols on both oncogenic and tumor‐suppressive lncRNAs in lung cancer, elucidating on their intricate regulatory mechanisms. The comprehensive examination extends to the potential synergies when combining polyphenols with conventional treatments like chemotherapy, radiation, and immunotherapy. Recognizing the heterogeneity of lung cancer subtypes, the review emphasizes the need for the integration of nanotechnology for optimized polyphenol delivery and personalized therapeutic approaches. In conclusion, we collect the latest research, offering a holistic overview of the evolving landscape of polyphenol‐mediated modulation of lncRNAs in lung cancer therapy. The integration of polyphenols and lncRNAs into multidimensional treatment strategies holds promise for enhancing therapeutic efficacy and navigating the challenges associated with lung cancer treatment.

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Section: Polyphenol Compoundsmentioning

confidence: 99%

Section: Polyphenol Compoundsmentioning

confidence: 99%

Modulation of long noncoding RNAs by polyphenols as a novel potential therapeutic approach in lung cancer: A comprehensive review

Lv,

Qian,

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…A common approach to obtain a wide variety of 3-substituted 4H-chromen-4-ones is using (E)-3-(dimethylamino)-1-(2-hydroxyaryl) prop-2-en-1-ones, commonly known as o-hydroxyaryl enaminones, as key intermediates, obtained mainly from the reaction of 2 0 -hydroxyacetophenones with DMF-DMA in DMF as solvent. Various 3-iodo-4H-chromen-4-ones arise from one-pot ring-closure and iodination sequence via addition of molecular iodine to o-hydroxyaryl enaminones employing methanol, [242][243][244][245][246][247] chloroform, 248,249 pyridine and chloroform, [250][251][252][253][254] pyridine and dichloromethane 47,255 as solvents, at room temperature. Examples of 3-fluoro-4H-chromen-4-ones were synthesized through the monofluorination of o-hydroxyaryl enaminones with Selectfluor ® as fluorine source in 1,2-DCE at room temperature, 256 in the presence of sodium acetate and butylated hydroxytoluene (BHT)…”

Section: Via O-hydroxyaryl Enaminone Formationmentioning

confidence: 99%