Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T

Araya, Eyleen; Rodríguez, Álex; Rubió, J.; Spada, Alessandro; Joglar, Jesús; Llebaría, Amadeu; Lagunas, Carmen; Fernández, Andrés G.; Spisani, Susanna; Pérez, Juan J.

doi:10.1016/j.bmcl.2004.12.071

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…The residue was purified by column chromatography to give 19 (109 mg, 85 %) as a white solid. 13 C‐decoupled 1 H NMR spectroscopic data matched those reported in the literature . HRMS: calcd.…”

Section: Methodssupporting

confidence: 74%

Synthesis of Isotope‐Labeled Deoxynivalenol‐15‐O‐Glycosides

et al. 2017

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A versatile and efficient protocol for the Schmidt glycosylation of 3‐acetyldeoxynivalenol (3‐ADON) and subsequent deprotection has been developed to gain access to deoxynivalenol‐15‐O‐glycosides in reasonable amounts for biological analysis and further investigations. By using this protocol with [13C6]glycosyl donors, we were able to prepare isotope‐labeled deoxynivalenol‐15‐O‐glycosides, which are pivotal to enabling accurate quantification of masked mycotoxins by LC–MS.

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Section: Methodssupporting

confidence: 74%

Synthesis of Isotope‐Labeled Deoxynivalenol‐15‐O‐Glycosides

et al. 2017

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“…The differences in binding affinities for MMP-2 and MMP-8 of the three phosphinates have been rationalized by means of modeling studies and MD simulations, also. In order to fully prove therapeutic benefits of Peptide T (ASTTTNYT), which is a fragment of the gp120 envelop protein of the human immunodeficiency virus (HIV), shown to inhibit binding of gp120 to the CD4, Araya et al [176], tried to design peptidomimetics of the peptide.…”

Section: Other Applicationsmentioning

confidence: 99%

Peptidomimetics and their Applications in Antifungal Drug Design

Moradi¹,

Soltani²,

Ansari³

et al. 2009

AIAMC

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The antimicrobial peptides represent diverse structures for drug design. They have been looked at as potential sources of new antimicrobial drugs to combat the increasing threat posed by multiple drug resistant microorganisms. Unfortunately, peptides themselves provide inferior drug candidates because of their low oral bioavailability, potential immunogenicity, poor in vivo metabolic stability, high molecular weight and most importantly being exposed by enzymes like proteases. Recent efforts to resolve disadvantageous peptide characteristics, and thus generating practical pharmaceutical therapies, have focused on the creation of non-natural peptide mimetics. Peptidomimetic molecules may have reduced immunogenicity and improved bioavailability relative to peptide analogues. Also the artificial backbone makes most peptidomimetics resistant to degradative enzymes thus increasing the stability of peptidomimetic drugs in the body. In this article, after introducing antifungal peptides, benefits and limitations, and peptidomemetics usage are discussed and applications in drug discovery process and antifungal research will be presented.

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“…It was thus tested as a therapeutic agent for the treatment of HIV infection and for the treatment of psoriasis. 72,73 Peptide hormones derived from the proopimelanocortin gene (POMC) are produced by epidermal cells (keratinocytes and melanocytes) and are known for their immunomodulating properties. POMC peptides in particular a-MSH, ACTH and b-endorphin have been demonstrated to affect inflammatory responses in different ways.…”

Section: Anti-inflammatory Peptidesmentioning

confidence: 99%