Synthesis and evaluation of antioxidant and antibacterial properties of morin complexes

Panhwar, Qadeer Khan; Memon, Shahabuddin

doi:10.1080/00958972.2011.590192

Cited by 38 publications

(18 citation statements)

References 45 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has two aromatic rings (A and B) linked by an oxygen‐containing heterocycle (C) as shown in Figure . Morin possesses antioxidant, anti‐inflammatory, anticancer and cardioprotective activities . Moreover, it acts as a chelating agent and its complexes play significant roles in human health .…”

Section: Introductionsupporting

confidence: 92%

Ga(III) complex with morin for kidney cancer cell labelling

Sentkowska

Kilian

Kopeć

et al. 2017

Applied Organom Chemis

View full text Add to dashboard Cite

The formation of a complex between Ga(III) and morin (3,5,7,2′,4′‐pentahydroxyflavone) was studied. UV–visible, infrared and mass spectroscopies were used to characterize the complex. The stoichiometric ratio for the reaction between metal ion and flavonoid was determined using the methods of Yoe–Jones and Job, which confirmed that a 1:1 Ga–morin complex was formed (estimated binding constant = 2.31 × 104 l mol−1). It was found that the coordination to Ga(III) occurs through the carbonyl oxygen atom and the 3‐OH group of the morin molecule. According to developed conditions, complexation reaction with 68Ga was performed and the complex was used to label kidney cancer cells (CAKI‐1, CAKI‐2, ACHN and 786‐O). The knowledge gained from this study should be useful for the development of new radiopharmaceuticals for diagnostic purposes containing 68Ga.

show abstract

Section: Introductionsupporting

confidence: 92%

Ga(III) complex with morin for kidney cancer cell labelling

Sentkowska

Kilian

Kopeć

et al. 2017

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…After 1.5 h stirring time, the complex mixture was filtered through gravity filtration method and evaporated the filtrate slowly at room temperature. The dark brownish yellow product of Mn(II)-Morin complex was obtained [28]. Washed the product with t-butanol, dried it in vaccum desiccator, while the yield was calculated as 73%.…”

Section: Synthesis Of the Complexmentioning

confidence: 99%

“…in an oven. The disks were placed on the petri dishes with nutrient agar containing cultures of bacteria in lawn fashion [28].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Synthesis, Characterization and Biological Activity of Mn(II)-Morin Complex

Memon¹

2016

Pak. J. Anal. Enviro. Chem.

Self Cite

View full text Add to dashboard Cite

“…The 1 H NMR data allow some conclusions on the chelation site: rutin chelates metal ions via 3c,4c-phenolic hydrogen, and in return the metal ions remove phenolic hydrogen from rutin [24][25][26]. The proton signals of Tin(II)-rutin complex are shifted to high field relative to its ligand, especially the G values of 2c-, 5c-, and 6c-H.…”

mentioning

confidence: 91%

Synthesis, Spectral and Antioxidant Properties of Tin(II)-Rutin Complex

et al. 2014

View full text Add to dashboard Cite

Rutin is one of the most common flavonoids present in nature that has a wide range of biological properties. A Tin(II)-rutin complex was synthesized from the raw material rutin and SnCl 2 in an alkaline solution. The complex was characterized by UV-vis, IR, 1 H NMR, and 13 C NMR spectroscopy. We evaluated the free radical scavenging activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, and the results showed that pure rutin was more effective than the Tin(II)-rutin complex in terms of antioxidant activity. Supplementing diet by foods rich in rutin and other flavonoids, such as vegetables and fruits, may contribute to removing free radicals and heavy metal ions in our body.Tinplate, commonly known as tin-plated steel sheet, is a kind of cold-rolled low-carbon steel sheet coated with pure tin on both sides. This material combines the durable strength of steel with the corrosion resistance of tin in one. These characteristics are the reasons why tinplate is widely used in the manufacture of rigid containers, especially for food and beverage packaging. Normally the concentration of tin in the majority of foods should be less than 1 part per million (ppm); however, in canned foods, especially those with an acidic pH, noticeably higher levels or more may be found [e.g., 100-500 ppm (0.01-0.05%)]. Regular consumption of these foods will cause symptoms of tin poisoning, such as vomiting, diarrhea, and anorexia [1].Chelation therapy is the preferred method for reducing the heavy metal induced toxicity. Chelating agents tightly bind to toxic metal ions to form complex structures that are easily excreted from the body [2]. Flavonoids are polyphenolic natural products widely distributed in plant foods, with a wide range of biological activities and pharmacological properties such as cardiovascular protection, anti-cancer, anti-ulcer, anti-oxidation, anti-viral, and anti-inflammatory; in addition, flavonoids are also natural antioxidants, free radical scavengers, and metal chelators [3]. Rutin is one of the most common flavonoids present in nature that has a wide range of biological properties, such as anti-inflammatory [4], anticancer [5], antioxidant [6], and so on. Rutin is an effective metal chelator [7, 8]. The complexation of metal cations by rutin has already been reported for a large number of metals: Zn (II), Al (III) [9], Cu (II) [10], Co (II) [11], Fe (II) [12], Fe (III) [13], Mn (II) [14], V (II) [15], U (II) [16], and Au (III) [17]. Rutin has attracted the attention of many researchers because of these special properties [18]. Supplementing regular diet with foods rich in rutin and other flavonoids, such as ginkgo biloba and buckwheat, may contribute to removing free radicals and heavy metal ions in our body [19,20].The purpose of this investigation was to study the chelating properties of rutin with tin cations [Sn(II)] and investigate the variation in antioxidant properties of rutin after chelation.The UV-vis spectrum of free rutin and Tin(II)-rutin complex in MeOH is reported in Fig. 1. Rutin exhibit...

show abstract

Synthesis and evaluation of antioxidant and antibacterial properties of morin complexes

Cited by 38 publications

References 45 publications

Ga(III) complex with morin for kidney cancer cell labelling

Ga(III) complex with morin for kidney cancer cell labelling

Synthesis, Characterization and Biological Activity of Mn(II)-Morin Complex

Synthesis, Spectral and Antioxidant Properties of Tin(II)-Rutin Complex

Contact Info

Product

Resources

About