Synthesis and evaluation of antioxidant and antibacterial behavior of CuO nanoparticles

Das, Dhaneswar; Nath, Bikash Chandra; Phukon, Pinkee; Dolui, Swapan Kumar

doi:10.1016/j.colsurfb.2012.07.002

Cited by 380 publications

(166 citation statements)

References 21 publications

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“…34 In the present work, the diffraction patterns were observed to be at 2θ = 32.47, 35.49, 38.68, 48.65, 53.36, 58.25 and 61.45 were assigned to the reflection lines of monoclinic CuO nanoparticles. The present experimental results were found to be in agreement with the reported diffraction patterns of CuO nanoparticles prepared by Das et al 35 …”

Section: Xrd Analysissupporting

confidence: 82%

Green synthesis of copper oxide nanoparticles using gum karaya as a biotemplate and their antibacterial application

Padil¹,

Černík²

2013

IJN

211

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Background:Copper oxide (CuO) nanoparticles have attracted huge attention due to catalytic, electric, optical, photonic, textile, nanofluid, and antibacterial activity depending on the size, shape, and neighboring medium. In the present paper, we synthesized CuO nanoparticles using gum karaya, a natural nontoxic hydrocolloid, by green technology and explored its potential antibacterial application. Methods: The CuO nanoparticles were synthesized by a colloid-thermal synthesis process. The mixture contained various concentrations of CuCl 2 ⋅ 2H 2 O (1 mM, 2 mM, and 3 mM) and gum karaya (10 mg/mL) and was kept at 75°C at 250 rpm for 1 hour in an orbital shaker. The synthesized CuO was purified and dried to obtain different sizes of the CuO nanoparticles. The well diffusion method was used to study the antibacterial activity of the synthesized CuO nanoparticles. The zone of inhibition, minimum inhibitory concentration, and minimum bactericidal concentration were determined by the broth microdilution method recommended by the Clinical and Laboratory Standards Institute. Results: Scanning electron microscopy analysis showed CuO nanoparticles evenly distributed on the surface of the gum matrix. X-ray diffraction of the synthesized nanoparticles indicates the formation of single-phase CuO with a monoclinic structure. The Fourier transform infrared spectroscopy peak at 525 cm −1 should be a stretching of CuO, which matches up to the B 2u mode.The peaks at 525 cm −1 and 580 cm −1 indicated the formation of CuO nanostructure. Transmission electron microscope analyses revealed CuO nanoparticles of 4.8 ± 1.6 nm, 5.5 ± 2.5 nm, and 7.8 ± 2.3 nm sizes were synthesized with various concentrations of CuCl 2 ⋅ 2H 2 O (1 mM, 2 mM, and 3 mM). X-ray photoelectron spectroscopy profiles indicated that the O 1s and Cu 2p peak corresponding to the CuO nanoparticles were observed. The antibacterial activity of the synthesized nanoparticles was tested against Gram-negative and positive cultures. Conclusion:The formed CuO nanoparticles are small in size (4.8 ± 1.6 nm), highly stable, and have significant antibacterial action on both the Gram classes of bacteria compared to larger sizes of synthesized CuO (7.8 ± 2.3 nm) nanoparticles. The smaller size of the CuO nanoparticles (4.8 ± 1.6 nm) was found to be yielding a maximum zone of inhibition compared to the larger size of synthesized CuO nanoparticles (7.8 ± 2.3 nm). The results also indicate that increase in precursor concentration enhances an increase in particle size, as well as the morphology of synthesized CuO nanoparticles.

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Section: Xrd Analysissupporting

confidence: 82%

Green synthesis of copper oxide nanoparticles using gum karaya as a biotemplate and their antibacterial application

Padil¹,

Černík²

2013

IJN

211

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“…Cellular membrane disruptions can lead to cell enzyme malfunction and eventually cell death. 98 CuNPs display greater antibacterial activity than CuONPs, which may be attributed to a better electron transfer between the bacteria and CuNPs. The slightly negative bacteria and the metallic nanoparticles act as good electron acceptors, both contributing to the electron transfer and rupture of the bacteria membrane.…”

mentioning

confidence: 99%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

500

358

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The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment.

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“…It has been reported that many of the metal nanoparticles can scavenge free radicals and act as antioxidants [49]. Moreover, a study by [36] reported that the antioxidant activity is mainly due to high surface to volume ratio of the nanostructures. Similarly, ZnO nanoparticles have shown to possess 91% scavenging activity at 250 mg/mL concentration [50].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Similarly, ZnO nanoparticles have shown to possess 91% scavenging activity at 250 mg/mL concentration [50]. In another study, CuO nanoparticles at 120 mg/mL concentration showed 85% DPPH quenching activity [36]. Also, CoFe2O4, Fe2O4 and NiO nanoparticles were shown to exhibit relatively good antioxidant characteristics compared to their bulk materials [51][52][53].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

et al. 2016

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Spinel copper ferrite (CuFe 2 O 4 ) and zinc ferrite (ZnFe 2 O 4 ) nanoparticles were synthesized using a sol-gel self-combustion technique. The structural, functional, morphological and magnetic properties of the samples were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). XRD patterns conform to the copper ferrite and zinc ferrite formation, and the average particle sizes were calculated by using a transmission electron microscope, the measured particle sizes being 56 nm for CuFe 2 O 4 and 68 nm for ZnFe 2 O 4. Both spinel ferrite nanoparticles exhibit ferromagnetic behavior with saturation magnetization of 31 emug´1 for copper ferrite (50.63 Am 2 /Kg) and 28.8 Am 2 /Kg for zinc ferrite. Both synthesized ferrite nanoparticles were equally effective in scavenging 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radicals. ZnFe 2 O 4 and CuFe 2 O 4 nanoparticles showed 30.57%˘1.0% and 28.69%˘1.14% scavenging activity at 125 µg/mL concentrations. In vitro cytotoxicity study revealed higher concentrations (>125 µg/mL) of ZnFe 2 O 4 and CuFe 2 O 4 with increased toxicity against MCF-7 cells, but were found to be non-toxic at lower concentrations suggesting their biocompatibility.

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Synthesis and evaluation of antioxidant and antibacterial behavior of CuO nanoparticles

Cited by 380 publications

References 21 publications

Green synthesis of copper oxide nanoparticles using gum karaya as a biotemplate and their antibacterial application

Green synthesis of copper oxide nanoparticles using gum karaya as a biotemplate and their antibacterial application

Antibacterial properties and toxicity from metallic nanomaterials

Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

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