Synthesis and Evaluation of a Zinc Eluting rGO/Hydroxyapatite Nanocomposite Optimized for Bone Augmentation

Chopra, Vianni; Thomas, Jijo; Sharma, Anjana; Panwar, Vineeta; Kaushik, Swati; Sharma, Shivani; Porwal, Konica; Kulkarni, Chirag; Rajput, Swati; Singh, Himalaya; Jagavelu, Kumaravelu; Chattopadhyay, Naibedya; Ghosh, Deepa

doi:10.1021/acsbiomaterials.0c00370

Cited by 36 publications

(48 citation statements)

References 87 publications

(181 reference statements)

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“…When Zinc is doped into HA, it will endow many functions to HA. Zn-HA can show excellent bioactivity, osteogenesis ability, anti-inflammatory effect and antibacterial ability [39][40][41]. Thus, Zn-HA has been widely investigated and applied.…”

Section: Zinc Doped Hydroxyapatite (Zn-ha)mentioning

confidence: 99%

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

et al. 2021

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Hydroxyapatite (HA) is widely used in bone tissue engineering for its bioactivity and biocompatibility, and a growing number of researchers are exploring ways to improve the physical properties and biological functions of hydroxyapatite. Up to now, HA has been used as inorganic building blocks for tissue engineering or as nanofillers to blend with polymers, furthermore, various methods such as ion doping or surface modification have been also reported to prepare functionalized HA. In this review, we try to give a brief and comprehensive introduction about HA-based materials, including ion-doped HA, HA/polymer composites and surface modified HA and their applications in bone tissue engineering. In addition, the prospective of HA is also discussed. This review may be helpful for researchers to get a general understanding about the development of hydroxyapatite based materials.

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Section: Zinc Doped Hydroxyapatite (Zn-ha)mentioning

confidence: 99%

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

et al. 2021

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“…[ 175 , 185 , 186 , 187 , 188 , 189 , 190 ] In terms of biological performances, bGBMs promote adhesion, [ 169 , 179 , 191 , 192 ] proliferation, [ 171 , 172 , 174 , 175 , 179 , 193 ] and osteogenic differentiation of stem cells. [ 142 , 169 , 171 , 176 , 179 , 186 , 191 , 192 ] When implanted in vivo, bGBMs promote new bone formation [ 178 , 182 , 186 , 191 , 194 , 195 ] and neovascularization, [ 196 , 197 ] with no adverse inflammatory response. [ 198 , 199 ] Due to the existence of GFMs, bGBMs also present antibacterial properties.…”

Section: Discussionmentioning

confidence: 99%

Development of Graphene‐Based Materials in Bone Tissue Engineaering

et al. 2021

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Currently, general treatments of criticalsized bone defects include autografts, allografts, and the use of bone regeneration biomaterials. [1] Autograft is the gold standard approach due to its satisfying osteogenicity. But it also faces drawbacks such as an invasive surgical operation for bone harvest and scarcity of available donor sites. [2] Allograft is accompanied by the risk of disease transmission and immunological rejection. [2] Therefore, significant efforts have been devoted to finding alternative approaches for bone regeneration. Bone tissue engineering (BTE) provides a promising alternative strategy to realize higher-level restoration of bone defects. BTE exploits the elaborate combination of scaffolds, seeding cells, and biological factors to form a functional substitute or assist in situ regeneration. In most BTE research, stem cells are implanted into defective bone sites with the support of a biomaterial-based scaffold and are supposed to proliferate and differentiate into osteoblasts to promote bone regeneration. However, the performances of many current BTE systems could not meet the therapeutic expectation due to problems such as insufficient osteogenic differentiation and limited vascularization. [3][4][5] Many studies tried to improve the performance of BTE via enhancing the properties of the biomaterial-based scaffold. [6] In addition to traditional macroor microscale forms of metals, ceramics, and polymers, their nanoscale counterparts have been extensively explored for BTE due to their unique properties. [7][8][9][10] Ever since Andre Geim and Konstantin Novoselov [11] discovered a simple and feasible method for graphene isolation, graphene family materials (GFMs) have attracted great interest in regenerative medicine and tissue engineering. In BTE, bGBMs show promising potentials such as mechanical strength, high specific surface, and adsorption ability. [12][13][14][15][16][17] According to the composition, bGBMs could be categorized into GFMs and GFMs-containing composite materials (GCMs). GFMs refer to graphene and its derivatives, containing 0D graphene quantum dots (GQDs), 2D graphene (GR), graphene oxide (GO), and reduced graphene oxide (rGO), 3D graphite, etc. Among them, GQDs, GR, GO, and rGO could be obtained by chemical approaches using graphite as the starting material. GCMs are composite materials consisting of GFMs and other materials such Bone regeneration-related graphene-based materials (bGBMs) are increasingly attracting attention in tissue engineering due to their special physical and chemical properties. The purpose of this review is to quantitatively analyze mass academic literature in the field of bGBMs through scientometrics software CiteSpace, to demonstrate the rules and trends of bGBMs, thus to analyze and summarize the mechanisms behind the rules, and to provide clues for future research. First, the research status, hotspots, and frontiers of bGBMs are analyzed in an intuitively and vividly visualized way. Next, the extracted important subjects such as fabricatio...

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“…Comprehensive findings of these experiments revealed: Strontium-doped hydroxyapatite showed increased osteoblast proliferation and differentiation [ 89 , 90 ]. Zinc-doped hydroxyapatite induced differentiation of mesenchymal stem cells to osteoblasts, migration and proliferation of endothelial cells and antimicrobial activity against Staphylococcus aureus [ 91 , 92 ]. Silver-doped hydroxyapatite demonstrated enhanced antibacterial activity and osteoblast adhesion when silver was used in low concentrations; higher concentrations of silver had a negative effect on osteoblast cell proliferation [ 93 , 94 , 95 ].…”

Section: Recent Advances In Biomaterials For Periodontal Regenerationmentioning

confidence: 99%

Role of Biomaterials Used for Periodontal Tissue Regeneration—A Concise Evidence-Based Review

Varghese

Rajagopal

2022

Polymers

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Periodontal infections are noncommunicable chronic inflammatory diseases of multifactorial origin that can induce destruction of both soft and hard tissues of the periodontium. The standard remedial modalities for periodontal regeneration include nonsurgical followed by surgical therapy with the adjunctive use of various biomaterials to achieve restoration of the lost tissues. Lately, there has been substantial development in the field of biomaterial, which includes the sole or combined use of osseous grafts, barrier membranes, growth factors and autogenic substitutes to achieve tissue and bone regeneration. Of these, bone replacement grafts have been widely explored for their osteogenic potential with varied outcomes. Osseous grafts are derived from either human, bovine or synthetic sources. Though the biologic response from autogenic biomaterials may be better, the use of bone replacement synthetic substitutes could be practical for clinical practice. This comprehensive review focuses initially on bone graft replacement substitutes, namely ceramic-based (calcium phosphate derivatives, bioactive glass) and autologous platelet concentrates, which assist in alveolar bone regeneration. Further literature compilations emphasize the innovations of biomaterials used as bone substitutes, barrier membranes and complex scaffold fabrication techniques that can mimic the histologically vital tissues required for the regeneration of periodontal apparatus.

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Synthesis and Evaluation of a Zinc Eluting rGO/Hydroxyapatite Nanocomposite Optimized for Bone Augmentation

Cited by 36 publications

References 87 publications

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Development of Graphene‐Based Materials in Bone Tissue Engineaering

Role of Biomaterials Used for Periodontal Tissue Regeneration—A Concise Evidence-Based Review

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