Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Shi, Hui; Zhou, Ziqi; Li, Wuda; Fan, Yuan; Li, Zhihua; Wei, Junchao

doi:10.3390/cryst11020149

Cited by 123 publications

(55 citation statements)

References 149 publications

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“…MgHA facilitates new bone formation and apposition on bone implants, controlling the initial dissolution rate and addressing bone regeneration [ 14 ]. It was previously demonstrated that MgHA has significant antibacterial and larvicidal ability against various pathogens [ 15 ], particularly bacteria such as Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli [ 16 ].…”

Section: Bioactive Ion-doped Nanohydroxyapatitesmentioning

confidence: 99%

Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability

et al. 2021

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Material science is a relevant discipline in support of regenerative medicine. Indeed, tissue regeneration requires the use of scaffolds able to guide and sustain the natural cell metabolism towards tissue regrowth. This need is particularly important in musculoskeletal regeneration, such as in the case of diseased bone or osteocartilaginous regions for which calcium phosphate-based scaffolds are considered as the golden solution. However, various technological barriers related to conventional ceramic processing have thus far hampered the achievement of biomimetic and bioactive scaffolds as effective solutions for still unmet clinical needs in orthopaedics. Driven by such highly impacting socioeconomic needs, new nature-inspired approaches promise to make a technological leap forward in the development of advanced biomaterials. The present review illustrates ion-doped apatites as biomimetic materials whose bioactivity resides in their unstable chemical composition and nanocrystallinity, both of which are, however, destroyed by the classical sintering treatment. In the following, recent nature-inspired methods preventing the use of high-temperature treatments, based on (i) chemically hardening bioceramics, (ii) biomineralisation process, and (iii) biomorphic transformations, are illustrated. These methods can generate products with advanced biofunctional properties, particularly biomorphic transformations represent an emerging approach that could pave the way to a technological leap forward in medicine and also in various other application fields.

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Section: Bioactive Ion-doped Nanohydroxyapatitesmentioning

confidence: 99%

Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability

et al. 2021

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“…Various types of hydroxyapatite reinforced materials (ion-doped HA, pure HA, or HA/polymer composites) have been investigated in experimental studies, clinical trials or systematic reviews. Although those materials are known to have non-immunogenic properties, are biocompatible and bioactive, and with good bone conductivity, there are also some disadvantages to be mentioned, such as brittleness and quick aggregation [21]. Nevertheless, due to the lack of toxic and allergenic properties, in dentistry, hydroxyapatite is used for coating dental implants, as a bone substitute, bone cement, or as a component of composite materials, dental cements and toothpastes [22].…”

Section: Of 19mentioning

confidence: 99%

Dental Applications of Systems Based on Hydroxyapatite Nanoparticles—An Evidence-Based Update

et al. 2021

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Hydroxyapatite is one of the most studied biomaterials in the medical and dental field, because of its biocompatibility; it is the main constituent of the mineral part of teeth and bones. In dental science, hydroxyapatite nanoparticles (HAnps) or nano-hydroxyapatite (nano-HA) have been studied, over the last decade, in terms of oral implantology and bone reconstruction, as well in restorative and preventive dentistry. Hydroxyapatite nanoparticles have significant remineralizing effects on initial enamel lesions, and they have also been used as an additive material in order to improve existing and widely used dental materials, mainly in preventive fields, but also in restorative and regenerative fields. This paper investigates the role of HAnps in dentistry, including recent advances in the field of its use, as well as their advantages of using it as a component in other dental materials, whether experimental or commercially available. Based on the literature, HAnps have outstanding physical, chemical, mechanical and biological properties that make them suitable for multiple interventions, in different domains of dental science. Further well-designed randomized controlled trials should be conducted in order to confirm all the achievements revealed by the in vitro or in vivo studies published until now.

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“…The addition of titanium particles was also proposed as a promising approach to improve the mechanical properties [252]. Titanium and its alloys are considered as some of the most attractive and important materials due to their unique properties, such as high tensile strength, resistance to body fluid effects, flexibility, and high corrosion resistance.…”

Section: Particlesmentioning

confidence: 99%

Toughening of Bioceramic Composites for Bone Regeneration

et al. 2021

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Bioceramics are widely considered as elective materials for the regeneration of bone tissue, due to their compositional mimicry with bone inorganic components. However, they are intrinsically brittle, which limits their capability to sustain multiple biomechanical loads, especially in the case of load-bearing bone districts. In the last decades, intense research has been dedicated to combining processes to enhance both the strength and toughness of bioceramics, leading to bioceramic composite scaffolds. This review summarizes the recent approaches to this purpose, particularly those addressed to limiting the propagation of cracks to prevent the sudden mechanical failure of bioceramic composites.

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Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Cited by 123 publications

References 149 publications

Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability

Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability

Dental Applications of Systems Based on Hydroxyapatite Nanoparticles—An Evidence-Based Update

Toughening of Bioceramic Composites for Bone Regeneration

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