Synthesis and electrochemistry of oxo- and sulfido-bridged molybdenum(V) complexes with 1,1-dithiolate ligands

Screening of biological properties of MoV2O2S2- and MoV2O4-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass

“…It suggests that his antioxidant ability depends on the redox properties of the Mo(V) centers which can be tuned with the nature of the coordinated ligand and by its oxo or sulfurated environment and more importantly from the ligand's redox properties itself. [20,21,53,59] The stability of the EDTA could also play a role by protecting the Mo(V) centers from oxidation, a process which leads to the breaking of the Mo-Mo bond and possibly to the decomposition of the compound, [60] while coordination of two separate ligands on each side of the Mo2O2E2 core leads to more labile structures and with higher ability to be oxidized. The combination of the aforementioned factors made K2[Mo2O2S2(L-cys)2].5H2O and Na2[Mo2O4(L-cys)2].5H2O to act as good small molecular-weight nonenzymatic antioxidants.…”

“…[17][18][19] In particular, since Mo (+V) binuclear complexes were interesting as models for redox active centers of molybdoenzymes, detailed electrochemical studies were performed in aqueous or in organic solvents to show the reversible or quasi-reversible cyclic processes of step-by-step one-electron reduction of the two Mo (+V) atoms to Mo (+IV) in the [Mo2O2E2] 2+ core in non-aqueous media. [20][21][22][23] However, surprisingly, to the best of our knowledge, no direct biological properties of [Mo2O2S2] 2+ and [Mo2O4] 2+ -based complexes were reported until a recent paper of Gretarsdóttir et al in which six simple complexes combining the [Mo2O2S2] 2+ core and ligands such as disulfides, tetrasulfides, cyclopentadiene Cp, DMF, Serine, Cysteine or threonine have been suggested to have biological potential. Their convenient low cytotoxicity on cells was considered useful for possible therapeutic applications like the development of catalytic drugs.…”

Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2]2+ core

“…7 Conversely, Mo(VI)O 3 has high oxidation state and its reaction chemistry in vivo and in water is characterized by hydrolysis and reduction of the molybdenum. 18 Redox chemistry of MoOSL n mononuclear compounds is deactivated by dimerization to form Mo(V) dimers 18 such as presented here with a very robust "Mo 2 O 2 S 2 " core structure resistant to redox chemistry at acidic and neutral pH. 19 Organometallic anticancer drugs and development of catalytic drugs place cytotoxicity and physical properties such as water solubility of the potential drugs at the forefront of challenges to overcome.…”

Regioselective and reversible carbon–nitrogen bond formation: Synthesis, structure and reactivity of ureato-bridged complexes [Mo2(NAr)2(µ-X){µ-ArNC(O)NAr}(S2CNR2)2] (Ar = Ph, p-tol; X = S, NAr; R = Me, Et, Pr)

“…All reactions were carried out under an inert atmosphere unless otherwise stated. Molybdenum complexes, 18 and syn-[MoO(l-S)(S 2 CNR 2 )] 2 18 were prepared by literature methods. All isocyanates and isothiocyanates were used as supplied.…”