Screening of biological properties of MoV2O2S2- and MoV2O4-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass

In Vitro Characterization of a Threonine-Ligated Molybdenyl–Sulfide Cluster as a Putative Cyanide Poisoning Antidote; Intracellular Distribution, Effects on Organic Osmolyte Homeostasis, and Induction of Cell Death

“…At 48 h, the IC 50 of cis platin in A549 cells is 26 μM, which is about 19 times lower than that found for 2 . These results correlate with other molybdenum complexes and clusters that show aqueous solubility and have biocompatible ligands that were reported noncytotoxic. − ,, An observable trend is that biocompatible ligands are expected to display lower cytotoxicity (higher IC 50 values) although not without exceptions . Interestingly, the organometallic Cp 2 MoCl 2 is noncytotoxic, and replacing the chloride ligands with malonate or maltolato ligands also results in noncytotoxic compounds. , The compounds MoO 3 , MoS 2 , and MoS 4 2– have been shown to be relatively nontoxic in vitro and well tolerated in vivo , respectively. ,, MoO 3 nanoplates were proposed as a selective potential breast cancer treatment with cytotoxicity reported at 275 μg/mL (1.91 mM) toward invasive breast cancer cells (iMCF-7) .…”

“…These results correlate with other molybdenum complexes and clusters that show aqueous solubility and have biocompatible ligands that were reported noncytotoxic. [26][27][28]48,49 An observable trend is that biocompatible ligands are expected to display lower cytotoxicity (higher IC 50 values) 50 although not without exceptions. 51 Interestingly, the organometallic Cp 2 MoCl 2 is noncytotoxic, and replacing the chloride ligands with malonate or maltolato ligands also results in noncytotoxic compounds.…”

Synthesis, Structures, and Solution Studies of a New Class of [Mo2O2S2]-Based Thiosemicarbazone Coordination Complexes

“…Their convenient low cytotoxicity on cells was considered useful for possible therapeutic applications like the development of catalytic drugs, especially for cyanide detoxification, for instance. − Following this work, we recently published a screening study of a series of complexes of [Mo (V) 2 O 2 E 2 ] 2+ (E = O or S) with commercial polycarboxylate ligands demonstrating that the biological properties of such complexes strongly depend on the nature of the ligand. For instance, complexes of EDTA were not active for antioxidative properties, while the complexes synthesized with l -cysteine, l -histidine, and iminodiacetate ligands are highly active . These results prompt us to explore new families of complexes with ligands known to be highly bioactive.…”

“…For instance, complexes of EDTA were not active for antioxidative properties, while the complexes synthesized with L-cysteine, Lhistidine, and iminodiacetate ligands are highly active. 17 These results prompt us to explore new families of complexes with ligands known to be highly bioactive.…”

Biological Evaluation of a Series of Amine-Containing Mixed-Ligand Copper(II) Coordination Compounds with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

“…Thiosemicarbazones and coordination compounds of transition metals often exhibit antiproliferative and antioxidant activities (Pahontu et al, 2017). In most cases, the coordination of thiosemicarbazones to copper(II) ions leads to the most significant increase in biological activity compared to ions of other 3d metals (Fuior et al, 2022). A number of studies have shown that the introduction of various amines into the inner sphere of copper(II) thiosemicarbazonates leads to a change in their biological properties.…”