Synthesis and dispersion of polypyrrole nanoparticles in polyvinylpyrrolidone emulsion

Woo, Hak-Young; Jung, Woo-Gwang; Ihm, Dae-Woo; Kim, Jin‐Yeol

doi:10.1016/j.synthmet.2009.12.010

Cited by 55 publications

(33 citation statements)

References 21 publications

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“…Polypyrrole spherical nanoparticles (PPy-NS) were obtained by a modification of the method described before [37]. The synthesis was carried out using APS (0.08 M) as an oxidant of the aqueous solution (0.043 M) of the monomer (Py).…”

Section: Polypyrrole Nanospheres (Ppy-ns)mentioning

confidence: 99%

Smart Thermomechanochemical Composite Materials Driven by Different Forms of Electromagnetic Radiation

et al. 2020

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Photo-thermo-mechanochemical (P-T-MCh) nanocomposites provide a mechanical and/or chemical output (MCh) in response to a photonic (P) input, with the thermal (T) flux being the coupling factor. The nanocomposite combines a photon absorbing nanomaterial with a thermosensitive hydrogel matrix. Conjugated (absorbing in the near infrared (NIR, 750–850 nm) wavelength range) polymer (polyaniline, PANI) nanostructures are dispersed in cross-linked thermosensitive (poly(N-isopropylacrylamide), PNIPAM) hydrogel matrices, giving the nanocomposite P-T-MCh properties. Since PANI is a conductive polymer, electromagnetic radiation (ER) such as radiofrequency (30 kHz) and microwaves (2.4 GHz) could also be used as an input. The alternating electromagnetic field creates eddy currents in the PANI, which produces heat through the Joule effect. A new kind of “product” nanocomposite is then produced, where ER drives the mechanochemical properties of the material through thermal coupling (electromagnetic radiation thermomechanochemical, ER-T-MCh). Both optical absorption and conductivity of PANI depend on its oxidation and protonation state. Therefore, the ER-T-MCh materials are able to react to the surroundings properties (pH, redox potential) becoming a smart (electromagnetic radiation thermomechanochemical) (sER-T-MCh) material. The volume changes of the sER-T-MCh materials are reversible since the size and shape is recovered by cooling. No noticeable damage was observed after several cycles. The mechanical properties of the composite materials can be set by changing the hydrogel matrix. Four methods of material fabrication are described.

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Section: Polypyrrole Nanospheres (Ppy-ns)mentioning

confidence: 99%

Smart Thermomechanochemical Composite Materials Driven by Different Forms of Electromagnetic Radiation

et al. 2020

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“…PPy nanoparticles are very attractive for OCT imaging owing to their strong NIR absorption spectrum, which extends well beyond 1300 nm. Near‐monodisperse PPy nanoparticles from 20 to 400 nm in diameter can be prepared by careful control of the experimental conditions 25–27. In addition, protocols have been developed for antibody conjugation to enable specific binding of antigens 28, 29.…”

mentioning

confidence: 99%

Polypyrrole Nanoparticles: A Potential Optical Coherence Tomography Contrast Agent for Cancer Imaging

Matcher

et al. 2011

Advanced Materials

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“…The strategy used to fabricate the yolk–shell nanoplatform (PTC‐siRNA/PFH) is illustrated in Figure a. First, PPy nanoparticles are constructed through the emulsion polymerization method, and characterized by transmission electron microscopy (TEM). As depicted in Figure b(i), the PPy nanoparticles show uniform size of about 80 nm in diameter.…”

Section: Resultsmentioning

confidence: 99%

A Yolk–Shell Nanoplatform for Gene‐Silencing‐Enhanced Photolytic Ablation of Cancer

Guo

Tian

Yang

et al. 2018

Adv Funct Materials

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Noninvasive near-infrared (NIR) light responsive therapy is a promising cancer treatment modality; however, some inherent drawbacks of conventional phototherapy heavily restrict its application in clinic. Rather than producing heat or reactive oxygen species in conventional NIR treatment, here a multifunctional yolk-shell nanoplatform is proposed that is able to generate microbubbles to destruct cancer cells upon NIR laser irradiation. Besides, the therapeutic effect is highly improved through the coalition of small interfering RNA (siRNA), which is codelivered by the nanoplatform. In vitro experiments demonstrate that siRNA significantly inhibits expression of protective proteins and reduces the tolerance of cancer cells to bubble-induced environmental damage. In this way, higher cytotoxicity is achieved by utilizing the yolk-shell nanoparticles than treated with the same nanoparticles missing siRNA under NIR laser irradiation. After surface modification with polyethylene glycol and transferrin, the yolk-shell nanoparticles can target tumors selectively, as demonstrated from the photoacoustic and ultrasonic imaging in vivo. The yolkshell nanoplatform shows outstanding tumor regression with minimal side effects under NIR laser irradiation. Therefore, the multifunctional nanoparticles that combining bubble-induced mechanical effect with RNA interference are expected to be an effective NIR light responsive oncotherapy.

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Synthesis and dispersion of polypyrrole nanoparticles in polyvinylpyrrolidone emulsion

Cited by 55 publications

References 21 publications

Smart Thermomechanochemical Composite Materials Driven by Different Forms of Electromagnetic Radiation

Smart Thermomechanochemical Composite Materials Driven by Different Forms of Electromagnetic Radiation

Polypyrrole Nanoparticles: A Potential Optical Coherence Tomography Contrast Agent for Cancer Imaging

A Yolk–Shell Nanoplatform for Gene‐Silencing‐Enhanced Photolytic Ablation of Cancer

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