Synthesis and degradation characteristics of salicylic acid-derived poly(anhydride-esters)

Erdmann, Lars; Uhrich, Kathryn E.

doi:10.1016/s0142-9612(00)00073-9

Cited by 180 publications

(187 citation statements)

References 17 publications

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“…Erdmann et al [49] have reported salicylic acid -based polymers in year 2000 and these have then been investigated extensively in the last few years. These salicylatebased polyanhydride -esters were collectively referred to as PolyAspirin because they hydrolytically degrade into salicylic acid, a nonsteroidal anti -infl ammatory drug.…”

Section: Salicylate -Based Polyanhydridesmentioning

confidence: 99%

Polyanhydrides

Domb¹,

Jain²,

Kumar³

2011

Handbook of Biodegradable Polymers

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Section: Salicylate -Based Polyanhydridesmentioning

confidence: 99%

Polyanhydrides

Domb¹,

Jain²,

Kumar³

2011

Handbook of Biodegradable Polymers

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“…M W of the copolyanhydrides decreases with an increase in dMOCPS fraction, which is similar to other copolyanhydrides containing SA residues. 3,4,25 Thermal properties of the copolyanhydrides were evaluated with DSC (Table I). It can be seen that glass-transition temperatures (T g ) of P(dMOCPS:SA) decreases from 52 to 9°C as dMOCPS content in- creases to 50%, then increases to 116°C in the case of P(dMOCPS) homopolymer, revealing a negative linearity of T g as a function of monomer fraction.…”

Section: Synthesis and Characterization Of The Copolyanhydridesmentioning

confidence: 99%

The effect of substitution levels on the luminescent and degradation properties of fluorescent poly(ester‐anhydride)s

Fan¹,

Jiang²,

Chen³

et al. 2006

J of Applied Polymer Sci

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ABSTRACT:In this work, two kinds of diacid monomers were synthesized by a convenient scheme, where 4-hydroxy-3-methoxybenzoic acid (vanillic acid) or 4-hydroxy-3,5-dimethoxybenzoic acid (syringic acid) directly condensated with succinic chloride. Corresponding polyanhydrides were obtained by melt polycondensation. Copolyanhydrides composed of the new monomers and sebacic acid (SA) were further prepared and characterized by NMR, DSC, and fluorometer. The two new kinds of polyanhydride emit strong fluorescence and have similar fluorescent spectra to poly(di(p-carboxyphenyl) succinate anhydride) (P(d-CPS)). The emission wavelength ( em ) of the copolymers could be tuned by the excitation wavelength ( ex ). Degradation rate of the copolyanhydrides decreased as dMOCPS or ddMOCPS fraction increased, and the degradation duration could be modulated from several days to more than 3 months. It addition, the copolyanhydrides displayed typical surface-degradation characteristics.

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“…[14][15][16] Polymer 1 is unique in that the drug 2 is chemically incorporated into the polymer backbone, not attached as a side group nor physically admixed within the polyanhydride matrix by melting or dissolving the polymer. Thus, drug release is directly dependent on the hydrolytic cleavage of the anhydride and ester bonds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of antiseptic-based poly(anhydride-esters)

Schmeltzer

Uhrich

2006

Polym. Bull.

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Poly(anhydride-esters) were prepared from catechol, fenticlor and hexachlorophene. The molecular weights (M w ) of the polymers were typically > 10,000 Da with glass transition temperatures (T g ) ranging from 23 to 84 °C. The thermal characteristics of the polymers paralleled the melting temperatures of the chemically incorporated antiseptic molecules. The in vitro release of the chemically incorporated antiseptic molecules were monitored over a 12 week period. For comparison, the in vitro release of physically admixed antiseptic molecules were also observed.After 12 weeks, the polymers were not completely degraded with drug release ranging from less than 1 to 55 %. Sessile-drop contact angles indicated that the polymers were relatively hydrophobic, contributing to the slow polymer degradation rates.

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Synthesis and degradation characteristics of salicylic acid-derived poly(anhydride-esters)

Cited by 180 publications

References 17 publications

Polyanhydrides

Polyanhydrides

The effect of substitution levels on the luminescent and degradation properties of fluorescent poly(ester‐anhydride)s

Synthesis and characterization of antiseptic-based poly(anhydride-esters)

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