Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives

Synthesis of Amides from Aliphatic Acids and Amines by using of I2/TBHP at Room Temperature

“…The thioglycolic acid reacts with aniline, 4‐fluoro, 4‐ bromo, 4‐chloro, 4‐methyl and 4‐methoxy aniline provides well in respected products ( 6 b–6 f ). The optimization condition subjected to bulky substituted amines also converted into desired products, like 2′ react with acetic acid, thioglycolic acid and 2‐phenoxyacetic gave respected products ( 2′a–2′c ) in 79, 50 and 61% of yields (Scheme ) …”

Synthesis of novel 1,2,4-triazole derivatives containing the quinazolinylpiperidinyl moiety and N-(substituted phenyl)acetamide group as efficient bactericides against the phytopathogenic bacterium Xanthomonas oryzae pv. oryzae

“…Intermediates 6a-6p were synthesized using a modied method reported by Barker et al 27 A mixture of substituted aniline (3.11 mmol) and dry triethylamine (1.5 mL) in dry 1,4-dioxane (6 mL) was stirred at 0 C for 5 min, and then bromoacetyl bromide (10.54 mmol) dissolved in the dried dioxane (6 mL) was added dropwise to the above solution and continued to stir for 5 h at room temperature. Finally, the reaction mixture was poured into cold water and the resulted precipitate was ltered off, washed with water and dried to afford amides 6a-6p in 57-96% yield.…”

Thieno[2,3-b]pyridine derivatives are potent anti-platelet drugs, inhibiting platelet activation, aggregation and showing synergy with aspirin

“…Unless noted, chemical reagents were used as purchased. Acetamides 5a-c were obtained using literature methods [29,[53][54][55]. -1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonitrile 4.…”