Synthesis and Cytotoxicity of Salicylate-Based Poly(anhydride esters)

Schmeltzer, Robert C.; Schmalenberg, Kristine E.; Uhrich, Kathryn E.

doi:10.1021/bm049544+

Cited by 61 publications

(86 citation statements)

References 59 publications

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“…Though initially there was no signifi cant reduction in bone loss, after 8 weeks signifi cant reduction in the bone, weight loss was observed in the polymer group [50] . In another study, polymers prepared from salicylic acid derivative were evaluated for cytotoxicity using L929 fi broblast cells in serum -containing medium on parameters like cell viability, proliferation, and morphology and these were found normal for most of the polymers evaluated [51] .…”

Section: Salicylate -Based Polyanhydridesmentioning

confidence: 99%

Polyanhydrides

Domb¹,

Jain²,

Kumar³

2011

Handbook of Biodegradable Polymers

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Section: Salicylate -Based Polyanhydridesmentioning

confidence: 99%

Polyanhydrides

Domb¹,

Jain²,

Kumar³

2011

Handbook of Biodegradable Polymers

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“…They contain hydrophobic compounds which are bound by hydrolytically labile anhydride bonds, and the rate of their degradation can be controlled by altering polymer composition (Schmeltzer et al, 2005). Anhydrides added to packaging films made of natural polymers have shown a potential antimicrobial activity 5 .…”

Section: Applications Of Antimicrobialsmentioning

confidence: 99%

Antimicrobial food packaging: potential and pitfalls

2015

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Nowadays food preservation, quality maintenance, and safety are major growing concerns of the food industry. It is evident that over time consumers’ demand for natural and safe food products with stringent regulations to prevent food-borne infectious diseases. Antimicrobial packaging which is thought to be a subset of active packaging and controlled release packaging is one such promising technology which effectively impregnates the antimicrobial into the food packaging film material and subsequently delivers it over the stipulated period of time to kill the pathogenic microorganisms affecting food products thereby increasing the shelf life to severe folds. This paper presents a picture of the recent research on antimicrobial agents that are aimed at enhancing and improving food quality and safety by reduction of pathogen growth and extension of shelf life, in a form of a comprehensive review. Examination of the available antimicrobial packaging technologies is also presented along with their significant impact on food safety. This article entails various antimicrobial agents for commercial applications, as well as the difference between the use of antimicrobials under laboratory scale and real time applications. Development of resistance amongst microorganisms is considered as a future implication of antimicrobials with an aim to come up with actual efficacies in extension of shelf life as well as reduction in bacterial growth through the upcoming and promising use of antimicrobials in food packaging for the forthcoming research down the line.

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“…PCL-SAPAE membranes were synthesized according to previously described methods. [29][30][31][32] The FD-SAPAE polymer (poly[1,6-bis(o-carboxyphenoxy) hexanoate]) had an average molecular weight (Mw) of 13,400, polydispersity index (PDI) of 1.7, and a glass transition temperature (Tg) of 46°C (Fig. 1B).…”

Section: Figmentioning

confidence: 99%

Salicylic Acid-Based Polymers for Guided Bone Regeneration Using Bone Morphogenetic Protein-2

Subramanian

Mitchell

et al. 2015

Tissue Engineering Part A

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Bone morphogenetic protein-2 (BMP-2) is used clinically to promote spinal fusion, treat complex tibia fractures, and to promote bone formation in craniomaxillofacial surgery. Excessive bone formation at sites where BMP-2 has been applied is an established complication and one that could be corrected by guided tissue regeneration methods. In this study, anti-inflammatory polymers containing salicylic acid [salicylic acid-based poly(anhydrideester), SAPAE] were electrospun with polycaprolactone (PCL) to create thin flexible matrices for use as guided bone regeneration membranes. SAPAE polymers hydrolyze to release salicylic acid, which is a nonsteroidal anti-inflammatory drug. PCL was used to enhance the mechanical integrity of the matrices. Two different SAPAE-containing membranes were produced and compared: fast-degrading (FD-SAPAE) and slow-degrading (SD-SAPAE) membranes that release salicylic acid at a faster and slower rate, respectively. Rat femur defects were treated with BMP-2 and wrapped with FD-SAPAE, SD-SAPAE, or PCL membrane or were left unwrapped. The effects of different membranes on bone formation within and outside of the femur defects were measured by histomorphometry and microcomputed tomography. Bone formation within the defect was not affected by membrane wrapping at BMP-2 doses of 12 mg or more. In contrast, the FD-SAPAE membrane significantly reduced bone formation outside the defect compared with all other treatments. The rapid release of salicylic acid from the FD-SAPAE membrane suggests that localized salicylic acid treatment during the first few days of BMP-2 treatment can limit ectopic bone formation. The data support development of SAPAE polymer membranes for guided bone regeneration applications as well as barriers to excessive bone formation.

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Synthesis and Cytotoxicity of Salicylate-Based Poly(anhydride esters)

Cited by 61 publications

References 59 publications

Polyanhydrides

Polyanhydrides

Antimicrobial food packaging: potential and pitfalls

Salicylic Acid-Based Polymers for Guided Bone Regeneration Using Bone Morphogenetic Protein-2

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