Synthesis and Cytotoxicity of Derivatives of Dipterocarpol, a Metabolite of Dipterocarpus alatus

Synthesis and properties of 2-cyanoethoxy derivatives of dammarane triterpenoids

“…The precipitate was filtered off, washed, dried, and recrystallized from a mixture petroleum ether-ethyl acetate. Yield 2.4 g (60%), mp 132-134°C (134-135°С [16]). The spectral data were consistent with the published information [21].…”

“…According to published information natural triterpenoids of dammarane series exhibit a wide range of biologic action [14][15][16][17], yet few data on preparation and properties of semisynthetic derivatives of this series are reported. We showed formerly that the dammarane triterpenoid alninkanone [20(S),24(R)-20,24-epoxy-24-methyldammaran-3-one] 1 exhibited a pronounced inhibiting activity with respect to influenza viruses of types А (Н3N2) and В (Hong Kong flu) [18].…”

Newly synthesised oxime and lactone derivatives from Dipterocarpus alatus dipterocarpol as anti-diabetic inhibitors: experimental bioassay-based evidence and theoretical computation-based prediction

“…3H, s), 1.36 (3H, s), 0.97 (3H, s), 0.93 (3H, s), 0.90 (6H, brs). 13 27,30 This compound was used as the starting material for the synthesis of the oxime and lactone derivatives.…”

“…It was reported that dipterocarpol and its derivatives exhibit antituberculosis, 27 antimicrobial, 28 hepatoprotective, 29 and cytotoxic activity. 30 In this work, two different approaches to modify the structure of dipterocarpol are proposed based on their advantages reported in the literature. The modication of the ring at C-3 of dipterocarpol to obtain oxime and its acyl derivatives (Fig.…”

Antibacterial Activity of Dipterocarpus alatus Twig Extract against Methicillin-Resistant Staphylococcus aureus (MRSA)

“…10 Dipterocarpol derivatives, which are major constituents of D. alatus, have shown cytotoxic effects and antimicrobial activity against S. aureus, Candida albicans, and Cryptococcus neoformans. 11,12 In our recent report, crude methanol extracts from several parts (barks, leaves, oleo-resin, wood, and twigs) of the D. alatus tree were shown to have antibacterial effects against MRSA, and the twig extracts showed the highest potency against MRSA with associated wound-healing effects. 13 Therefore, in the current study, a range of organic solvents and methods were used to make D. alatus twig extracts to identify the optimal extracts inhibiting MRSA.…”