Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives

Radwan, Eman M.; El‐Sayed, Elsherbiny H.; El‐Moneim, Mohamed Abd; Moustafa, Amal M. Youssef

doi:10.1007/s11094-021-02535-5

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…Due to the complexity of the illness and the fact that several proteins and enzymes are dysregulated, therapies focusing on a single target have been unsuccessful thus far. On the basis of our previous work, we have found that some coumarin derivatives have shown very promising activities against carcinoid cells [20][21][22]. Therefore, we have continued this research on certain new hybrid coumarin compounds.…”

Section: Introductionmentioning

confidence: 94%

Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs

Al-Warhi,

Abu Ali,

Alqahtani

et al. 2023

Crystals

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Scientists have been interested in hybrid coumarin derivatives due to their wide clinical anticancer use. Herein, ethyl 8-methoxycoumarin-3-carboxylate (Compound 1) served as the starting material for the synthesis of a series of novel hybrid coumarin derivatives (Compounds 3–6). Their structure was determined using 13C NMR, 1H NMR, elemental analysis, and mass spectrometry. The in vitro cytotoxic activities of coumarin derivatives (Compounds 3, 5, and 6) and brominated coumarin derivatives (Compounds 4, 8, and 9) against MCF-7 and MDA-MB-231 were evaluated. Several substances have been identified as promising candidates for future study, especially Compound 6 due to its potent activity against β-tubulin (TUB) polymerization, sulfatase, and aromatase enzymes. It also has a role in inducing cell-cycle arrest at the S phase in the MCF-7 cell line, as well as apoptosis.

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Section: Introductionmentioning

confidence: 94%

Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs

Al-Warhi,

Abu Ali,

Alqahtani

et al. 2023

Crystals

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“…Coumarin dyes are widely used in uorescent probes because of their low biotoxicity, high uorescence sensitivity, good photostability and easy modi cation of the main chain [22][23][24][25][26][27][28][29][30] . Coumarin derivatives can also be used as uorescence markers or imaging agents to identify tumor lesions and study the subcellular localization of drugs [31][32][33][34][35][36][37][38][39][40][41][42] . In this paper, two novel uorescent probes were synthesized using coumarin with an aldehyde (CHO group) as the uorophore.…”

Section: Introductionmentioning

confidence: 99%

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Zhang

Huang

Wang

et al. 2023

Preprint

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Large accumulations of copper (Cu) ions in the human body may cause damage, including organ and brain damage. In recent years, studies have proven that a large accumulation of Cu ions can lead to Parkinson's disease and Alzheimer's disease, therefore it is great important to develop novel strategies for detecting trace Cu in environmental and biological samples. In this work, we designed two new coumarin-based colorimetric and fluorescent probes HQ1 and HQ2. These two probes could selectively respond to Cu2+ with obvious color and fluorescence changes, and the presence of other metal ions had no effect on these changes. The two probes also exhibited high sensitivity for Cu2+, with a detection limit as low as 1.81×10-8 M/ 1.57×10-8 M. Notably, the two probes showed potential practical applications and were successfully used for detecting Cu2+ in a test strip, A549 cells and living zebrafish larvae.

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“…[22][23][24][25][26][27][28][29][30][31][32] Coumarin derivatives can also be used as fluorescence markers or imaging agents to identify tumor lesions and study the subcellular localization of drugs. [33][34][35][36][37][38][39][40][41][42][43][44] The development of a sensor with high selectivity and sensitivity to copper ions remains an important challenge. In this paper, two novel fluorescent probes were synthesized using coumarin with an aldehyde (CHO group) as the fluorophore.…”

Section: Introductionmentioning

confidence: 99%

Two novel coumarin-based fluorescent probes for the detection of Cu²⁺ and biological applications

Zhang,

Huang,

Wang

et al. 2023

Journal of Chemical Research

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Large accumulations of copper (Cu) ions in the human body may cause damage, including organ and brain damage. In recent years, studies have proven that a large accumulation of Cu ions can lead to Parkinson’s disease and Alzheimer’s disease; therefore, it is great important to develop novel strategies for detecting trace Cu in environmental and biological samples. In this work, we designed two new coumarin-based colorimetric and fluorescent probes, HQ1 and HQ2. These two probes could selectively respond to Cu2+ with obvious color and fluorescence changes, and the presence of other metal ions had no effect on these changes. The two probes also exhibited high sensitivity for Cu2+, with a detection limit as low as 1.81 × 10–8 M/1.57 × 10–8 M. Notably, the two probes showed potential practical applications and were successfully used for detecting Cu2+ in a test strip, A549 cells, and living zebrafish larvae.

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Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives

Cited by 6 publications

References 27 publications

Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs

Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Two novel coumarin-based fluorescent probes for the detection of Cu²⁺ and biological applications

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Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives

Cited by 6 publications

References 27 publications

Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs

Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Two novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Contact Info

Product

Resources

About

Two novel coumarin-based fluorescent probes for the detection of Cu²⁺ and biological applications