Synthesis and crystal structures of antimony(III) and tin(IV) compounds with an amino-amido-silane ligand

A series of new organotin(IV) compounds [Me2SnL], [Et2SnL], [Bu2SnL] and [Ph2SnL], where L = 2-hydroxy-N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)ethylidene)benzohydrazide has been synthesized by refluxing methyl salicylate hydrazide hydrate with dehydroacetic acid (DHA) with the corresponding organotin(IV) chlorides. All the compounds were characterized by elemental analyses, FT-IR, 1H NMR, 13C NMR, 119Sn NMR and mass spectrometry. The synthesized complexes found to have wide therapeutic potential.

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Synthesis, Characterization and Antimicrobial Screening of Some Organotin Complexes Derived from Salicyl Hydrazide Schiff Bases

Priyanka

Tuli

Aggarwal³

et al. 2021

Asian J. Chem.

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New Schiff Base Derived Organotin (IV) Complexes: Synthesis, Characterization, In vitro and In silico Biological Studies

Kumar,

Siwach,

Sharma

et al. 2024

AIA

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Aims: The creation and testing of new Schiff base-based antibacterial organotin (IV) complexes were the objectives of this investigation. background: Due to developed resistance, antibiotics that were once often used to treat microorganisms are no longer effective against them. It is thought that organotin compounds synthesized from Schiff bases have significant pharmacological effectiveness and work well as antibacterial agents Background: Due to developed resistance, antibiotics that were once often used to treat microor-ganisms are no longer effective against them. It is thought that organotin compounds synthesized from Schiff bases have significant pharmacological effectiveness and work well as antibacterial agents. Methods: Thiocarbohydrazide and dehydroacetic acid were condensed to create the Schiff base, followed by processing with dialkyltin(IV)dichloride to synthesize the final product. Modern an-alytical techniques were used to clarify the compounds' probable structural details. The crystalline nature of the produced compounds was tested using PXRD. Results: All of the compounds were thermally stable up to 300°C. All of the synthesized com-plexes showed potent antibacterial activity in the range of 250 to 400 μg/ml. Furthermore, the computational biology research showed that, in contrast to ligands, which had a binding energy of -7.3 to -7.4 kcal/mol, complexes interacted well with dihydropteroate synthase and DNA gy-rase. Conclusion: The current study offered a unique technique for synthesizing diorganotin(IV) de-rivatives of N-substituted Schiff bases that are physiologically active. The results show that the chemicals created are promising antibacterial mediators against diseases that affect humans in the modern world. It might also open the door to future studies on drug-resistant microorganisms that could have biological uses.

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Synthesis and crystal structures of antimony(III) and tin(IV) compounds with an amino-amido-silane ligand

Cited by 2 publications

References 35 publications

Synthesis, Characterization and Antimicrobial Screening of Some Organotin Complexes Derived from Salicyl Hydrazide Schiff Bases

Synthesis, Characterization and Antimicrobial Screening of Some Organotin Complexes Derived from Salicyl Hydrazide Schiff Bases

New Schiff Base Derived Organotin (IV) Complexes: Synthesis, Characterization, In vitro and In silico Biological Studies

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