Synthesis and coronary vasodilating activity of 1-aminopyrazolo[3,4-b]pyridines with fused tetrahydropyran (-thiopyran) and piperidine rings

Дабаева, В. В.; Pilosyan, S. G.; Noravyan, A. S.; Bagdasaryan, M. P.; Grigoryan, G. Kh.; Aleksanyan, R. A.

doi:10.1007/s11094-009-0218-y

“…Recently, there has been a rise in interest in synthetic antioxidants as a potential treatment,To stop fats from oxidizing, it is utilized in the pharmaceutical and cosmetic sectors.Piperidine derivatives, or imidazolidine derivatives, have a variety of pharmacological effects, including antitubercular effects. (Aridoss et al, 2008), HeLa cell cytotoxicity (Parthiban et al, 2011), antihypertensive (Watanuki et al, 2011), anticancer (Girgis, 2009), coronary vasodilation (Dabaeva et al, 2008), and antiarrhythmic properties (Abdel-Aziz et al,2009). According to Czopek et al (2010), derivatives of imidazolidine-2,4-dione have pharmacological activities like anxiolytic and antimalarial properties (Araujo et al, 2005), In order to synthesize piperidine with imidazolidine derivatives and test its anticoagulant and anticancer properties, these references will serve as the primary bases.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of 2-Thioxo Imidazolidin-4-ones in male rats exposed to oxidative stress by hydrogen peroxide in drinking water

Jiheel

¹

,

Zayir

²

,

Abdullaha

³

2022

ijhs

0

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In the present study, a new Thioxoimidazolidine derivative had been preparedasligand, L=(3{(E)[(4bromophenyl) methyldenamino2sulfanylideneimidazolidin-4-one. This ligand was synthesized by the reaction of 4-bromobenzaldehyde with thiosemicarbazide, then, the product was reacted with chloroethylacetate in an ethanol medium. The final product was isolated and characterized by suitable physical measurements, FT-IR, UV-Vis spectrophotometer, GC-mass spectrophotometer, and 1H-NMR spectroscopy as well as elemental analysis (CHNS). for assessment of the antioxidant activity of this new ligand in vivo we used twenty-four mature albino male rats divided into three equal groups, the first group served as control and received a normal diet and drank from tap water, while the other groups received a normal diet and drinking of 0.5%hydrogen peroxide, third group dosage by 50mg/kg of Thioxoimidazolidine daily. The results showed a decrease in GSH Catalase and total antioxidant concentrations of animals of selected groups when treated with 0.5% v/v of hydrogen peroxide, while a significant elevation in serum GSH, Catalase, and total antioxidant concentrations in another group after treatment with Thioxoimidazolidine of ligand.

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“…Piperidine derivatives, or imidazolidine derivatives, have a variety of pharmacological effects, including antitubercular effects. (Aridoss et al, 2008), HeLa cell cytotoxicity (Parthiban et al, 2011), antihypertensive (Watanuki et al, 2011), anticancer (Girgis, 2009), coronary vasodilation (Dabaeva et al, 2008), and antiarrhythmic properties (Abdel-Aziz et al,2009). According to Czopek et al (2010), derivatives of imidazolidine-2,4-dione have pharmacological activities like anxiolytic and antimalarial properties (Araujo et al, 2005), In order to synthesize piperidine with imidazolidine derivatives and test its anticoagulant and anticancer properties, these references will serve as the primary bases.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of 2-Thioxo Imidazolidin-4-Ones in male rats exposed to oxidative stress by hydrogen peroxide in drinking water

Ja

¹

,

Zayir

²

,

Abdullahab

³

2022

ijhs

0

View full text Add to dashboard Cite

In the present study, a new Thioxoimidazolidine derivative had been preparedasligand, L=(3{(E)[(4bromophenyl) methyldenamino2sulfanylideneimidazolidin-4-one. This ligand was synthesized by the reaction of 4-bromobenzaldehyde with thiosemicarbazide, then, the product was reacted with chloroethylacetate in an ethanol medium. The final product was isolated and characterized by suitable physical measurements, FT-IR, UV-Vis spectrophotometer, GC-mass spectrophotometer, and 1H-NMR spectroscopy as well as elemental analysis (CHNS). for assessment of the antioxidant activity of this new ligand in vivo we used twenty-four mature albino male rats divided into three equal groups, the first group served as control and received a normal diet and drank from tap water, while the other groups received a normal diet and drinking of 0.5%hydrogen peroxide, third group dosage by 50mg/kg of Thioxoimidazolidine daily. The results showed a decrease in GSH Catalase and total antioxidant concentrations of animals of selected groups when treated with 0.5% v/v of hydrogen peroxide, while a significant elevation in serum GSH, Catalase, and total antioxidant concentrations in another group after treatment with Thioxoimidazolidine of ligand.

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Synthesis of New Fused Pyrano[4,3-b]pyridines from Ethyl 3-Aminopyrano[4,3-b]thieno[3,2-e]pyridine-2-carboxylate

Dabayeva

¹

,

Baghdasaryan

²

,

Paronikyan

³

et al. 2023

Russ J Org Chem

2

0

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Synthesis and coronary vasodilating activity of 1-aminopyrazolo[3,4-b]pyridines with fused tetrahydropyran (-thiopyran) and piperidine rings

Cited by 5 publications

References 1 publication

Antioxidant activity of 2-Thioxo Imidazolidin-4-ones in male rats exposed to oxidative stress by hydrogen peroxide in drinking water

Antioxidant activity of 2-Thioxo Imidazolidin-4-ones in male rats exposed to oxidative stress by hydrogen peroxide in drinking water

Antioxidant activity of 2-Thioxo Imidazolidin-4-Ones in male rats exposed to oxidative stress by hydrogen peroxide in drinking water

Synthesis of New Fused Pyrano[4,3-b]pyridines from Ethyl 3-Aminopyrano[4,3-b]thieno[3,2-e]pyridine-2-carboxylate

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