Antioxidant activity of 2-Thioxo Imidazolidin-4-ones in male rats exposed to oxidative stress by hydrogen peroxide in drinking water

Abstract

In the present study, a new Thioxoimidazolidine derivative had been preparedasligand, L=(3{(E)[(4bromophenyl) methyldenamino2sulfanylideneimidazolidin-4-one. This ligand was synthesized by the reaction of 4-bromobenzaldehyde with thiosemicarbazide, then, the product was reacted with chloroethylacetate in an ethanol medium. The final product was isolated and characterized by suitable physical measurements, FT-IR, UV-Vis spectrophotometer, GC-mass spectrophotometer, and 1H-NMR spectroscopy as well as elemental analysis (CHNS). for assessment of the antioxidant activity of this new ligand in vivo we used twenty-four mature albino male rats divided into three equal groups, the first group served as control and received a normal diet and drank from tap water, while the other groups received a normal diet and drinking of 0.5%hydrogen peroxide, third group dosage by 50mg/kg of Thioxoimidazolidine daily. The results showed a decrease in GSH Catalase and total antioxidant concentrations of animals of selected groups when treated with 0.5% v/v of hydrogen peroxide, while a significant elevation in serum GSH, Catalase, and total antioxidant concentrations in another group after treatment with Thioxoimidazolidine of ligand.