Synthesis and characterizations of biodegradable and crosslinkable poly(-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer

Wang, Shanfeng; Lu, Lichun; Gruetzmacher, James A.; Currier, Bradford L.; Yaszemski, Michael J.

doi:10.1016/j.biomaterials.2005.07.013

Cited by 141 publications

(166 citation statements)

References 16 publications

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“…The compressive moduli of P(PF-co-CL) scaffolds ranged from 44 to 142 MPa, similar to human trabecular bone. 17,18 These results indicate that P(PF-co-CL) may be a promising candidate material to substitute PMMA in vertebraplsty. 20,21 In this study, we evaluated the biomechanical performance of the copolymer in a cadaver model of vertebral lytic lesions.…”

Section: Fig 3 (A B)mentioning

confidence: 81%

“…17,18 The copolymer formulation with 50/50 ratio of poly(propylene fumarate) (PPF) and poly(caprolactone) (PCL) was used based on previous studies demonstrating good biocompatibility and suitable mechanical properties for use as a synthetic bone substitute. 18,19 The degradation rate of P(PF-co-CL) can be varied by changing the copolymer composition, molecular weight, and crosslinking parameters.…”

Section: Introductionmentioning

confidence: 99%

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Biomechanical Evaluation of an Injectable and Biodegradable Copolymer P(PF-co-CL) in a Cadaveric Vertebral Body Defect Model

Fang

Giambini

Zeng

et al. 2014

Tissue Engineering Part A

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A novel biodegradable copolymer, poly(propylene fumarate-co-caprolactone) [P(PF-co-CL)], has been developed in our laboratory as an injectable scaffold for bone defect repair. In the current study, we evaluated the ability of P(PF-co-CL) to reconstitute the load-bearing capacity of vertebral bodies with lytic lesions. Forty vertebral bodies from four fresh-frozen cadaveric thoracolumbar spines were used for this study. They were randomly divided into four groups: intact vertebral body (intact control), simulated defect without treatment (negative control), defect treated with P(PF-co-CL) (copolymer group), and defect treated with poly(methyl methacrylate) (PMMA group). Simulated metastatic lytic defects were made by removing a central core of the trabecular bone in each vertebral body with an approximate volume of 25% through an access hole in the side of the vertebrae. Defects were then filled by injecting either P(PF-co-CL) or PMMA in situ crosslinkable formulations. After the spines were imaged with quantitative computerized tomography, single vertebral body segments were harvested for mechanical testing. Specimens were compressed until failure or to 25% reduction in body height and ultimate strength and elastic modulus of each specimen were then calculated from the forcedisplacement data. The average failure strength of the copolymer group was 1.83 times stronger than the untreated negative group and it closely matched the intact vertebral bodies (intact control). The PMMA-treated vertebrae, however, had a failure strength 1.64 times larger compared with the intact control. The elastic modulus followed the same trend. This modulus mismatch between PMMA-treated vertebrae and the host vertebrae could potentially induce a fracture cascade and degenerative changes in adjacent intervertebral discs. In contrast, P(PF-co-CL) restored the mechanical properties of the treated segments similar to the normal, intact, vertebrae. Therefore, P(PF-co-CL) may be a suitable alternative to PMMA for vertebroplasty treatment of vertebral bodies with lytic defects.

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Section: Fig 3 (A B)mentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Biomechanical Evaluation of an Injectable and Biodegradable Copolymer P(PF-co-CL) in a Cadaveric Vertebral Body Defect Model

Fang

Giambini

Zeng

et al. 2014

Tissue Engineering Part A

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“…Specifically, its utility for peripheral nerve regeneration as well as spinal cord regeneration, wound healing bone repair and muscle tissue stimulation have been claimed [61,62]. Electrically conductive polymer composites (PCLF-PPy) composed of polycaprolactone fumarate [63] (PCLF) and polypyrrole have been developed for nerve regeneration applications [64]. PCLF is a derivative of polycaprolactone ( Figure 18) that can be easily processed into complex three-dimensional structures and exhibits biocompatibility, good mechanical properties, and tunable degradation rates that make it a promising base material for application as nerve guidance conduits [65].…”

Section: Development Of Novel Biodegradable Polymes and Blends Based mentioning

confidence: 99%

Nanomembranes and Nanofibers from Biodegradable Conducting Polymers

et al. 2013

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Abstract:This review provides a current status report of the field concerning preparation of fibrous mats based on biodegradable (e.g., aliphatic polyesters such as polylactide or polycaprolactone) and conducting polymers (e.g., polyaniline, polypirrole or polythiophenes). These materials have potential biomedical applications (e.g., tissue engineering or drug delivery systems) and can be combined to get free-standing nanomembranes and nanofibers that retain the better properties of their corresponding individual components. Systems based on biodegradable and conducting polymers constitute nowadays one of the most promising solutions to develop advanced materials enable to cover aspects like local stimulation of desired tissue, time controlled drug release and stimulation of either the proliferation or differentiation of various cell types. The first sections of the review are focused on a general overview of conducting and biodegradable polymers most usually employed and the explanation of the most suitable techniques for preparing nanofibers and nanomembranes (i.e., electrospinning and spin coating). Following sections are organized according to the base conducting polymer (e.g., Sections 4-6 describe hybrid systems having aniline, pyrrole and thiophene units, respectively). Each one of these sections includes specific subsections dealing with applications in a nanofiber or nanomembrane form. Finally, miscellaneous systems and concluding remarks are given in the two last sections. OPEN ACCESSPolymers 2013, 5 1116

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“…35 The PCLF sample used here was synthesized using a,o-telechelic PCL diol with a nominal M n of 530 g mol À1 and fumaryl chloride in the presence of potassium carbonate. 36 Both PPF and PCLF are biodegradable, crosslinkable, and biocompatible. [37][38][39] Crosslinked PPF and PCLF have distinct characteristics because of different density of crosslinkable segment on the polymer backbone.…”

Section: Scaffold Materialsmentioning

confidence: 99%

Solute Transport in Cyclically Deformed Porous Tissue Scaffolds with Controlled Pore Cross-Sectional Geometries

Buijs

Jorgensen

et al. 2009

Tissue Engineering Part A

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The objective of this study was to investigate the influence of pore geometry on the transport rate and depth after repetitive mechanical deformation of porous scaffolds for tissue engineering applications. Flexible cubic imaging phantoms with pores in the shape of a circular cylinder, elliptic cylinder, and spheroid were fabricated from a biodegradable polymer blend using a combined 3D printing and injection molding technique. The specimens were immersed in fluid and loaded with a solution of a radiopaque solute. The solute distribution was quantified by recording 20 mm pixel-resolution images in an X-ray microimaging scanner at selected time points after intervals of dynamic straining with a mean strain of 8.6 AE 1.6% at 1.0 Hz. The results show that application of cyclic strain significantly increases the rate and depth of solute transport, as compared to diffusive transport alone, for all pore shapes. In addition, pore shape, pore size, and the orientation of the pore cross-sectional asymmetry with respect to the direction of strain greatly influence solute transport. Thus, pore geometry can be tailored to increase transport rates and depths in cyclically deformed scaffolds, which is of utmost importance when thick, metabolically functional tissues are to be engineered.

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Synthesis and characterizations of biodegradable and crosslinkable poly(-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer

Cited by 141 publications

References 16 publications

Biomechanical Evaluation of an Injectable and Biodegradable Copolymer P(PF-co-CL) in a Cadaveric Vertebral Body Defect Model

Biomechanical Evaluation of an Injectable and Biodegradable Copolymer P(PF-co-CL) in a Cadaveric Vertebral Body Defect Model

Nanomembranes and Nanofibers from Biodegradable Conducting Polymers

Solute Transport in Cyclically Deformed Porous Tissue Scaffolds with Controlled Pore Cross-Sectional Geometries

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