Synthesis and characterization of Zn(II) and Cd(II) complexes of S-benzyl-β-N-(2-pyridyl)methylenedithiocarbazate (HNNS): bioactivity of the HNNS Schiff base and its Zn(II), Cu(II) and Cd(II) complexes and the X-ray structure of the [Zn(NNS)2] complex

Tarafder, M. T. H.; Kasbollah, Azahari; Crouse, Karen A.; Ali, Abdul Manaf; Yamin, Bohari Mohd.; Fun, Hoong‐Kun

doi:10.1016/s0277-5387(01)00817-8

Cited by 119 publications

(42 citation statements)

References 23 publications

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“…It was obtained that, compounds 4and 5 showed antibacterial activity against all bacteria. These observations are similar to earlier report by Tarafder et al [28]. Among the tested compounds, compound 5 showed higher antibacterial ability followed by compound 4 against all studied bacteria.…”

Section: Antibacterial Activitysupporting

confidence: 92%

New Zinc (II) Phthalocyanines Substituents: Synthesis, Aggregation Behavior, Antioxidant, and Antibacterial Activity

2016

IJSR

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Abstract:The novel phthalonitrile derivatives bearing methyl 2-mercaptoacetate and methyl 3-mercaptopropanoate phthalonitrile substituents at peripheral position were preparedby a nucleophilic displacement reaction. Cyclotetramerization of these phthalonitrile derivatives in the presence of corresponding metal salts gave the new metallophthalocyanines. The novel compounds were characterized by using various spectroscopic data. The aggregation investigations carried out in different concentrations indicate that phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10 −4 -10 −6 M in tetrahydrofuran. In vitro three antioxidant test methods, namely (2, 2-diphenyl-1-picryl-hydrazyl) radical scavenging activity was used to determine the antioxidant activity of compounds. In addition to these, the antibacterial activities of compounds were investigated by using the disk-diffusion method.

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Section: Antibacterial Activitysupporting

confidence: 92%

New Zinc (II) Phthalocyanines Substituents: Synthesis, Aggregation Behavior, Antioxidant, and Antibacterial Activity

2016

IJSR

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“…According to previous studies [3,39], octahedral nickel(II) complexes with two unpaired electrons will have magnetic moments between 2.9 and 3.4 B.M which indicates a small but definite orbital contribution to the magnetic moment. The magnetic moments of the zinc(II) and cadmium(II) complexes were found to be diamagnetic, which indicated distorted octahedral structures [40]. All the complexes were non-electrolytes in DMSO, evidence that the two ligands moieties did not dissociate in solution [41].…”

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confidence: 98%

Synthesis, characterisation and biological activities of S-2- or S-4-methylbenzyl-β-N-(di-2-pyridyl)methylenedithiocarbazate and Cu(II), Ni(II), Zn(II) and Cd(II) complexes

et al. 2017

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Metal complexes of general formula, [M(NNS)2] (M = Cu(II), Ni(II), Zn(II) and Cd(II); NNS'= S-2-methylbenzyl-β-N-(di-2-pyridyl)methylenedithiocarbazate (1), NNS''= S-3-methylbenzyl-β-N-(di-2-pyridyl)methylenedithiocarbazate (2) and NNS'''= S-4-methylbenzyl-β-N-(di-2-pyridyl)methylenedithiocarbazate (3) have been synthesized by reacting the respective metal acetates with the Schiff bases in an ethanol/acetonitrile mixture. negative estrogen receptor) cell lines. Only 9 was active against MCF-7 whereas 10 and 13were active against the MDA-MB-231 cell line. Cytotoxic activity was observed to be enhanced upon complexation particularly for the Ni(II) complexes.Keywords: biological activities, S-R-methylbenzyldithiocarbazate, di-2-pyridylketone, Schiff bases IntroductionDithiocarbazate Schiff bases and their transition metal complexes [1-10] have been of considerable interest to scientists for many years as they show a wide range of therapeutic properties against various diseases, with different anti-bacterial, anti-malarial, anti-viral and anti-tumour properties [1][2][3][4][5][6][7][8][9][10]. In recent years, heterocyclic thiosemicarbazones and Schiff bases derived from S-alkyl dithiocarbazates have been considered as useful model compounds for sulphur-containing analogues of purine and pyrimidine bases [11][12][13]. The π-delocalisation of charge and the configurational flexibility of their molecular chain give rise to a great variety of coordination modes [14][15][16][17][18]. Their chemistry and pharmacological applications have been widely investigated as well [1][2][3][4][5][6][15][16][17][18].Coordination compounds, especially those that contain nitrogen-sulphur ligands are synthesized via relatively simple, cost-effective procedures and it has been observed that small changes in their structure, such as change of substituents and their chelation to different metal ions cause great changes in their bioactivities. The coordination of these compounds often lead to enhanced biological activity in several pathogenic fungi [3,[19][20][21]. Some of these metal complexes have been known to accelerate drug action and the efficacy of a therapeutic agent [1][2][3][4][5][6][19][20][21].The Schiff bases synthesized in this study are the di-2-pyridylketone Schiff bases of isomeric dithiocarbazates, S-2-methylbenzyldithiocarbazate, S-3-methylbenzyl dithiocarbazate and S-4-methylbenzyldithiocarbazate (Fig. 1). Investigations have shown that di-2-pyridylketone thiosemicarbazone and an analogue, 2-benzoylpyridine thiosemicarbazone, demonstrated marked and selective antitumour activity in vitro and also in vivo against many tumours. Di-2-pyridylketone thiosemicarbazone has also been found to possess several structural characteristics important for iron chelating efficacy and potent anti-proliferative activity, and can be further modified as anti-neoplastic agents. Iron has a crucial role in the active site of ribonuclease reductase which is the rate-limiting step of DNA synthesis. This Schiff base and other similar compounds h...

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“…China e-mail: zhaopusu@163.com ical activities, including the antitumour effects, but also having various coordination modes [4,5]. Consequently, many such ligands and their metal complexes are synthesized and studied [6][7][8]. The title compound of phenyl-thiocarbamic acid-O-pyridin-4-ylmethyl ester is a typical ligand having the atoms of N and S and its crystal structure has been obtained by our group.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure and density functional theoretical studies on phenyl-thiocarbamic acid-O-pyridin-4-ylmethyl ester

et al. 2006

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The title compound of phenyl-thiocarbamic acid-O-pyridin-4-ylmethyl ester has been synthesized and characterized by elemental analysis, IR, electronic spectroscopy and X-ray single crystal diffraction. Density functional theory (DFT) method calculations of the structure, atomic charge distributions and the thermodynamic properties at different temperatures have been performed. Calculated results show that DFT method at B3LYP/6-311G * * level can well reproduce the structure of the title compound. The predicted vibrational frequencies are compared with the experimental ones and they support each other on the whole. The atoms of sulfur, oxygen and the atom of nitrogen from pyridine ring all have bigger negative charges, which make the title compound become a multidentate organic ligand. The correlation equations of the thermodynamic properties of C • p,m and S • m with temperature are also obtained.

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Synthesis and characterization of Zn(II) and Cd(II) complexes of S-benzyl-β-N-(2-pyridyl)methylenedithiocarbazate (HNNS): bioactivity of the HNNS Schiff base and its Zn(II), Cu(II) and Cd(II) complexes and the X-ray structure of the [Zn(NNS)2] complex

Cited by 119 publications

References 23 publications

New Zinc (II) Phthalocyanines Substituents: Synthesis, Aggregation Behavior, Antioxidant, and Antibacterial Activity

New Zinc (II) Phthalocyanines Substituents: Synthesis, Aggregation Behavior, Antioxidant, and Antibacterial Activity

Synthesis, characterisation and biological activities of S-2- or S-4-methylbenzyl-β-N-(di-2-pyridyl)methylenedithiocarbazate and Cu(II), Ni(II), Zn(II) and Cd(II) complexes

Synthesis, crystal structure and density functional theoretical studies on phenyl-thiocarbamic acid-O-pyridin-4-ylmethyl ester

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