New Zinc (II) Phthalocyanines Substituents: Synthesis, Aggregation Behavior, Antioxidant, and Antibacterial Activity

Abstract

Abstract:The novel phthalonitrile derivatives bearing methyl 2-mercaptoacetate and methyl 3-mercaptopropanoate phthalonitrile substituents at peripheral position were preparedby a nucleophilic displacement reaction. Cyclotetramerization of these phthalonitrile derivatives in the presence of corresponding metal salts gave the new metallophthalocyanines. The novel compounds were characterized by using various spectroscopic data. The aggregation investigations carried out in different concentrations indicate that phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10 −4 -10 −6 M in tetrahydrofuran. In vitro three antioxidant test methods, namely (2, 2-diphenyl-1-picryl-hydrazyl) radical scavenging activity was used to determine the antioxidant activity of compounds. In addition to these, the antibacterial activities of compounds were investigated by using the disk-diffusion method.

Biological Performance of Hexadeca-Substituted Metal Phthalocyanine/Reduced Graphene Oxide Nanobioagents

“…The DPPH test is well known as a simple and rapid method frequently preferred to investigate the potential of a biological agent for the scavenging of free radicals. Antioxidants play a critical role in the treatment of various diseases by inhibiting the production or elimination of free radicals. , In this study, the antioxidant activities of nanobioagents 1 – 5 were investigated at various concentrations. The results are presented in Figure .…”

“…Jlali and Jamoussi synthesized peripherally tetra-substituted zinc(II) phthalocyanines bearing methyl 2-mercaptoacetate or methyl 3-mercaptopropanoate and studied their antioxidant features. As the concentration increased, their antioxidant activities enhanced …”