Synthesis and Characterization of Zinc Oxide Nanoparticles Using Cynara scolymus Leaves: Enhanced Hemolytic, Antimicrobial, Antiproliferative, and Photocatalytic Activity

Rajapriya, Mariappan; Sharmili, S. Aruna; Raju, Baskar; Balaji, Ravichandran; Alharbi, Naiyf S.; Kadaikunnan, Shine; Khaled, Jamal M.; Alanzi, Khalid F.; Vaseeharan, Baskaralingam

doi:10.1007/s10876-019-01686-6

Cited by 53 publications

(23 citation statements)

References 38 publications

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“…2 . The same diffraction value was noticed in ZnO-NPs using Lycopersicon esculentum and Cynara scolymus leaf extract [ 8 , 32 ]. In this study, the lattice planes clearly indicate that ZnO-NPs formation and its hexagonal phase and wurtzite structure of ZnO-NPs.…”

Section: Resultssupporting

confidence: 65%

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Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

et al. 2021

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In around the world, mosquito control is considered a most important because of the incapable of synthetic insecticides and the ecological pollution about by them. In this manner, need the eco-friendly insecticides to efficient control the mosquito disease is the need of the hour. We synthesized the eco-friendly of zinc oxide nanoparticles (ZnO-NPs) using the Knoxia sumatrensis aqueous leaf extract ( Ks- ALE) as a reducing and stabilizing agent. The synthesis of ZnO-NPs was confirmed by UV with an absorption peak at 354 nm. ZnO-NPs crystal structure was analyzed by X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FT-IR) spectra revealed the chloride, cyclic alcohols, sulfonamies, carboxylic acids, oximes, phosphines, alkenes and alcohol & phenol. Field emission-scanning electron microscopy (FE-SEM) showed that the NP’s are rod shaped with 50–80 nm size and also energy dispersive spectra (EDaX) spectra showed presence of zinc. Antioxidant assay showed superior activity and evidenced by DPPH, ABTS and H 2 O 2 radical assays. Furthermore, the ZnO-NPs exhibited strong activity in MCF-7 cell line with IC 50 value is 58.87 μg/mL. Mosquito larvicidal activity of ZnO-NPs produced significant activity and excellent larvicidal activity was noticed in Cx. quinquefasciatus with LC 50 0.08, mg/mL and LC 90 19.46 mg/mL. This study suggests that synthesized ZnO-NPs using Knoxia sumatrensis leaf extract have good biological activities and it makes them an ideal candidate for pharmacological studies.

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Section: Resultssupporting

confidence: 65%

“…In earlier report, were observed by Ulva lactuca - fabricated of ZnO-NPs [ 33 ]. In other results were finding in ZnO-NPs using Cynara scolymus leaf extract [ 32 ]. The spectra band at 434 cm −1 which is indicates that the formation of ZnO-NPs [ 34 ].…”

Section: Resultsmentioning

confidence: 94%

Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

et al. 2021

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“…In another study, MCF-7 and VERO cell lines were exposed to spherical shaped ZnO NPs having a diameter of 65.9 nm. Anti-proliferative capability was found due to the induction of apoptosis and thus can be considered safe in development of treatment methods [ 175 ]. Hence, it can be concluded that the plant-mediated ZnO NPs could be the most efficient anticancerous agents due to their strong therapeutic potential and low systemic toxicity.…”

Section: In Vitro and In Vivo Anticancerous Activity Of Zno Npsmentioning

confidence: 99%

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

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Hashim

Malik

et al. 2021

Cancers

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Cancer is regarded as one of the most deadly and mirthless diseases and it develops due to the uncontrolled proliferation of cells. To date, varieties of traditional medications and chemotherapies have been utilized to fight tumors. However, their immense drawbacks, such as reduced bioavailability, insufficient supply, and significant adverse effects, make their use limited. Nanotechnology has evolved rapidly in recent years and offers a wide spectrum of applications in the healthcare sectors. Nanoscale materials offer strong potential for curing cancer as they pose low risk and fewer complications. Several metal oxide NPs are being developed to diagnose or treat malignancies, but zinc oxide nanoparticles (ZnO NPs) have remarkably demonstrated their potential in the diagnosis and treatment of various types of cancers due to their biocompatibility, biodegradability, and unique physico-chemical attributes. ZnO NPs showed cancer cell specific toxicity via generation of reactive oxygen species and destruction of mitochondrial membrane potential, which leads to the activation of caspase cascades followed by apoptosis of cancerous cells. ZnO NPs have also been used as an effective carrier for targeted and sustained delivery of various plant bioactive and chemotherapeutic anticancerous drugs into tumor cells. In this review, at first we have discussed the role of ZnO NPs in diagnosis and bio-imaging of cancer cells. Secondly, we have extensively reviewed the capability of ZnO NPs as carriers of anticancerous drugs for targeted drug delivery into tumor cells, with a special focus on surface functionalization, drug-loading mechanism, and stimuli-responsive controlled release of drugs. Finally, we have critically discussed the anticancerous activity of ZnO NPs on different types of cancers along with their mode of actions. Furthermore, this review also highlights the limitations and future prospects of ZnO NPs in cancer theranostic.

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“…On the other hand, various studies have shown that zinc, chromium and their oxide NPs (ZnO, Cr 2 O 3 etc.) have different hemolytic activity according to their morphology, size and concentration [69][70][71][72][73]. In this study, ZnCr 2 O 4 NPs with appropriate concentration (0.5% w/w) were used and, as a result, the hemolytic activity of the cross-linked lignin-agarose/SF/ ZnCr 2 O 4 nanobiocomposite remains almost unchanged.…”

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confidence: 99%

Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

et al. 2021

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Synthesis and Characterization of Zinc Oxide Nanoparticles Using Cynara scolymus Leaves: Enhanced Hemolytic, Antimicrobial, Antiproliferative, and Photocatalytic Activity

Cited by 53 publications

References 38 publications

Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

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