Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

Abstract

In around the world, mosquito control is considered a most important because of the incapable of synthetic insecticides and the ecological pollution about by them. In this manner, need the eco-friendly insecticides to efficient control the mosquito disease is the need of the hour. We synthesized the eco-friendly of zinc oxide nanoparticles (ZnO-NPs) using the Knoxia sumatrensis aqueous leaf extract ( Ks- ALE) as a reducing and stabilizing agent. The synthesis of ZnO-NPs was confirmed by UV with an absorption peak at 354 nm. ZnO-NPs crystal structure was analyzed by X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FT-IR) spectra revealed the chloride, cyclic alcohols, sulfonamies, carboxylic acids, oximes, phosphines, alkenes and alcohol & phenol. Field emission-scanning electron microscopy (FE-SEM) showed that the NP’s are rod shaped with 50–80 nm size and also energy dispersive spectra (EDaX) spectra showed presence of zinc. Antioxidant assay showed superior activity and evidenced by DPPH, ABTS and H 2 O 2 radical assays. Furthermore, the ZnO-NPs exhibited strong activity in MCF-7 cell line with IC 50 value is 58.87 μg/mL. Mosquito larvicidal activity of ZnO-NPs produced significant activity and excellent larvicidal activity was noticed in Cx. quinquefasciatus with LC 50 0.08, mg/mL and LC 90 19.46 mg/mL. This study suggests that synthesized ZnO-NPs using Knoxia sumatrensis leaf extract have good biological activities and it makes them an ideal candidate for pharmacological studies.

Green synthesis of zinc oxide nanoparticles using Sea Lavender (Limonium pruinosum L. Chaz.) extract: characterization, evaluation of anti-skin cancer, antimicrobial and antioxidant potentials

“…The highest DPPH activity was recorded at 1000 μg/ml as 75.2% for ZnO NPs and 84.6% for L. pruinosum extract. In the present study the IC 50 of ZnO = 86.5 μg/ml, whereas Loganathan et al 15 have reported IC 50 = 95.80 μg/ml. L. pruinosum extract showed relatively higher antioxidant activity than their phyto-synthesized ZnO NPs due to the presence of secondary metabolites as confirmed by FT-IR and GC–MS results.…”

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

“…The MCF-7 cell line was also utilized to investigate anti-breast cancer cytotoxicity, and the findings demonstrate that ZnO NPs generated from root extract of Withania somnifera had significant cytotoxicity in a dose-dependent fashion [ 167 ]. ZnO NPs biosynthesized from Knoxia sumatrensis inhibited anti-proliferative activity on MCF-7 cell line [ 168 ]. In another study, ZnO nanorods were prepared using Santalum album and dose-dependent cytotoxicity was found against MCF-7 cells.…”

ROS-scavenging glyco-nanoplatform for synergistic antibacterial and wound-healing therapy of bacterial keratitis

“…Hydrogen peroxide solution (H 2 O 2 –FeSO 4 system) was prepared according to the method reported earlier. 30 The nanoparticle solution was mixed with an equal volume of hydrogen peroxide solution. After incubation at 37 °C for 1 h, the absorbance of the mixed solution was read at 510 nm.…”