Synthesis and characterization of ultrafine γ-Al2O3:Cr nanoparticles and their performance in antibacterial activity

Karimi, Merat; Kashi, M. Almasi; Montazer, A.H.

doi:10.1007/s10971-021-05557-3

Cited by 8 publications

(5 citation statements)

References 53 publications

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“…Finally, the black gel was calcined at 800 °C to induce a series of chemical reactions, including dehydration, dehydroxylation, and crystallization. These reactions transform the amorphous gel into crystalline Cr-doped Al 2 O 3 NPs, with chromium ions incorporated into the aluminum oxide lattice structure (Karimi et al 2021).…”

Section: Synthesis Of Cr-doped Al 2 O 3 Npsmentioning

confidence: 99%

Development of a novel nanoformulation based on aloe vera-derived carbon quantum dot and chromium-doped alumina nanoparticle (Al2O3:Cr@Cdot NPs): evaluating the anticancer and antimicrobial activities of nanoparticles in photodynamic therapy

Karimi,

Homayoonfal,

Zahedifar

et al. 2024

Cancer Nano

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The objective of this study was to synthesize a novel antibacterial and anticancer nanoformulation using aloe vera-derived carbon quantum dots (Cdot) and chromium-doped alumina nanoparticles (Al2O3:Cr/Cdot NPs) via a sol–gel method. X-ray diffraction (XRD) analysis confirmed crystalline NPs with a size range of 10–12 nm, while energy-dispersive X-ray spectroscopy (EDS) revealed their elemental composition without impurities. Fourier-transform infrared spectroscopy (FT-IR) indicated strong interactions between Cdot and Al2O3:Cr NPs, forming a robust heterostructure. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images provided visual confirmation of monodisperse, spherical NPs, ensuring uniformity for further applications. Evaluation of reactive oxygen species (ROS) demonstrated superior generation of singlet oxygen and hydroxyl radicals by Al2O3:Cr/Cdot NPs, essential for photodynamic therapy. Minimum inhibitory concentration (MIC) tests revealed potent antibacterial activity against drug-resistant bacteria, inhibiting biofilm formation by 89% and 95% for MRSA and P. aeruginosa PAO1, respectively. Furthermore, the anticancer activity of Al2O3:Cr/Cdot NPs was assessed using C26 cells, demonstrating enhanced cytotoxicity upon UVA exposure. The NPs exhibited an inhibitory concentration (IC50) of 20 μg/mL without UVA exposure, decreasing to 10 μg/mL with UVA exposure, highlighting the synergistic effect of UVA light in enhancing cytotoxicity. Overall, these findings underscore the significant potential of Al2O3:Cr/Cdot NPs as multifunctional agents for addressing drug-resistant bacteria and advancing cancer therapy, offering promising avenues for nanomedicine research and development.

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Section: Synthesis Of Cr-doped Al 2 O 3 Npsmentioning

confidence: 99%

Development of a novel nanoformulation based on aloe vera-derived carbon quantum dot and chromium-doped alumina nanoparticle (Al2O3:Cr@Cdot NPs): evaluating the anticancer and antimicrobial activities of nanoparticles in photodynamic therapy

Karimi,

Homayoonfal,

Zahedifar

et al. 2024

Cancer Nano

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“…Several metal oxide nanoparticles have been reported for their potential antibacterial activities against Gramnegative and Gram-positive bacteria, consisting of Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. These metal oxide nanoparticles include Al 2 O 3 (Jawad et al 2021;Karimi et al 2021), CuO, Cu 2 O, ZnO (Asamoah et al 2020;Karuppannan et al 2021;Han et al 2022;Khosravi et al 2022), CaO (Abbas and Aadim 2022), MnO 2 , MgO (Ogunyemi et al 2020;Amrulloh et al 2021), TiO 2 (Wang et al 2020;Zhang et al 2021), Fe 3 O 4 (Azizabadi et al 2021;Kamali et al 2022), Ag 2 O (Rashidi Ranjbar et al 2020;Dharmaraj et al 2021;Mahlambi and Moloto 2022), NiO (Kannan et al 2020;Christy et al 2021), and SiO 2 (Attallah et al 2022;Tran et al 2023). The antibacterial activity lies in its physical and chemical properties, which include morphology, chemical composition, particle size, surface characteristics, solubility, crystallinity, aggregation, and crystal phase.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic and antibacterial activities of cobalt and nickel nanoparticles: a comparative analysis

Balogun,

Abolarinwa,

Adesanya

et al. 2024

J Anal Sci Technol

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This study aimed to compare the spectroscopy, morphological, electrocatalytic properties, and antibacterial activities of cobalt nanoparticles (CoNPs) with nickel nanoparticles (NiNPs). Cobalt nanoparticles and NiNPs were prepared via a chemical reduction approach and characterized utilizing transmission electron microscopy (TEM), energy-dispersive X-ray (EDX), and X-ray diffraction (XRD) techniques. The result from XRD and TEM analysis revealed that the synthesized nanoparticles exhibit face-centered cubic with smooth spherical shape, having average particles size of 12 nm (NiNPs) and 18 nm (CoNPs). The electrochemical properties of the nanoparticles were examined via cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques. The CV results showed that GCE-Ni (35.6 μA) has a higher current response compared to GCE-Co (10.5 μA). The EIS analysis revealed that GCE-Ni (1.39 KΩ) has faster electron transport capability compared to GCE-Co (2.99 KΩ) as indicated in their Rct values. The power density of the synthesized nanoparticles was obtained from their "knee" frequency (f°) values, with GCE-Ni (3.16 Hz) having higher f° values compared to GCE-Co (2.00 Hz). The antibacterial activity of the nanoparticles was evaluated against multidrug-resistant Escherichia coli O157, Escherichia coli O177, Salmonella enterica, Staphylococcus aureus, and Vibrio cholerae. The result from the antibacterial study revealed that at low concentrations both CoNPs and NiNPs have significant antibacterial activities against E. coli O157, E. coli O177, S. enterica, S. aureus, and V. cholerae. NiNPs showed better antibacterial activities at low concentrations of 61.5, 61.5, 125, 61.5, and 125 µg/mL compared to CoNPs with minimum inhibitory concentrations of 125, 125, 250, 61.5, and 125 µg/mL against E. coli O157, E. coli O177, S. enterica, S. aureus, and V. cholerae, respectively. These promising antibacterial activities emphasize the potential of CoNPs and NiNPs as effective antibacterial agents, which could aid in the development of novel antibacterial medicines.

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“…From there, it must undergo intersystem crossing (ISC) to form the triplet excited state (T 1 ) or return to the ground state (S) through fluorescence or heat generation. The longlived T 1 PS can react with oxygen via two mechanisms (type I and II), generating a variety of ROS (Weston et al, 2016;Castilho et al, 2017;Karimi et al, 2021;Wang et al, 2022;Khorsandi et al, 2022;Liang et al, 2022). PDT can be used as therapeutic option for a variety of cancers, including esophageal, malignant glioma, bladder cancer, pharyngeal and oral cancer, lung cancer, skin cancer, liver, breast, and pancreatic cancer (Lu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

In vitro study: green synthesis and evaluation of MgO/C-dots/DOX phosphorescent nanocomposites for photodynamic/photocatalytic therapy of tumors

Karimi,

Sadeghi,

Zahedifar

et al. 2023

Front. Bioeng. Biotechnol.

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MgO nanoparticles (NPs) and carbon dots (C-dots) were synthesized by co-precipitation and hydrothermal techniques. In the next step, as-synthesized NPs were modified by C-dots. Then, polyethylene glycol (PEG) was conjugated with MgO/Cdots. Finally, Doxorubicin (Dox) as an anticancer drug was loaded on MgO/Cdots/PEG nanocomposites. The XRD pattern showed the characteristic peaks of C-dots and MgO. The FTIR spectrum showed that MgO/C-dots possessed the carboxyl functional groups, allowing DOX to be loaded onto MgO/C-dots/PEG through hydrogen bonds. The particle size of MgO, C-dots, MgO/C-dots, and MgO/C-dots/PEG/DOX was 20–30, 5–10, 30–40, and 100–130 nm, respectively, using TEM, DLS, and FESEM techniques. MgO, MgO/C-dots, and MgO/C-dots/DOX were fluorescent NPs when excited by a UV source. Anthracene and methylene blue were used as fluorescent probes to identify the reactive oxygen species (ROS) produced by UV excitation. The activity of MgO/C-dots and MgO/C-dots/DOX against colorectal cancer (C26) cells, after repeated 5-min illumination with both UV-light and red light LEDs, were measured by MTT assay. C26 cancer cells incubated with DOX-loaded MgO/C-dots and exposed to either wavelength (UV and red) killed ∼70% of cells. The green synthesized nanocomposites could act as anti-cancer photosensitizers probably by a photocatalytic mechanism.

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Synthesis and characterization of ultrafine γ-Al2O3:Cr nanoparticles and their performance in antibacterial activity

Cited by 8 publications

References 53 publications

Development of a novel nanoformulation based on aloe vera-derived carbon quantum dot and chromium-doped alumina nanoparticle (Al2O3:Cr@Cdot NPs): evaluating the anticancer and antimicrobial activities of nanoparticles in photodynamic therapy

Development of a novel nanoformulation based on aloe vera-derived carbon quantum dot and chromium-doped alumina nanoparticle (Al2O3:Cr@Cdot NPs): evaluating the anticancer and antimicrobial activities of nanoparticles in photodynamic therapy

Spectroscopic and antibacterial activities of cobalt and nickel nanoparticles: a comparative analysis

In vitro study: green synthesis and evaluation of MgO/C-dots/DOX phosphorescent nanocomposites for photodynamic/photocatalytic therapy of tumors

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