Synthesis and Characterization of Some 3-Nitroso-2-arylimidazo (1,2-α) pyrimidines

Larocca, Joseph P.; Gibson, Coy; Thompson, B. Blackburn

doi:10.1002/jps.2600600113

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1971

1991

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Cited by 9 publications

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“…General Method. 3-Nitroso-2-phenylimidazo[l,2-o]pyridine and 5-nitroso-6phenylimidazo [2,l-6]thiazole were obtained by a combination of methods described by Almirante et a!.5'6 and LaRocca et al 7 -Bromoacetophenone was condensed respectively with 2aminopyridine and 2-aminothiazole. The condensation products were suspended in 10% NaOH solution, extracted with CHCI3, and evaporated to dryness to obtain the respective free bases.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and antihypertensive activity of some imidazoindole derivatives

Pf¹,

Sk²,

Ba³

1976

J. Med. Chem.

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The synthesis of pyridino[1,2-a]imidazo[5,4-b]indole (1) and thiazolo[3,2-a-a]imidazo[5,4-b-a]indole (2) has been achieved by phosphite reduction of 3-nitroso-6-phenylimidazo[1,2-a]pyridine and 5-nitroso-6-phenylimidazo[2,1-bb]thiazole. Compound 1 has shown strong antihypertensive activity in spontaneously hypertensive rats while compound 2 showed similar bioactivity both in spontaneously hypertensive rats and in normotensive dogs. A tricyclic amino derivative, 3-amino-2-phenylimidazo[1,2-a]pyridine, which has structural resemblance to compound 1, showed no hypotensive activity.

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Section: Methodsmentioning

confidence: 99%