Synthesis and Characterization of Some Metal Complexes With Iets as Ligand Derived From 2-Acetlylindan-1,3-Dione

Kumar, D. Ravi; Singh, Vipin Kumar; Khiwar, S. S.; Saxena, Neeraj

doi:10.22270/jddt.v4i1.758

Cited by 3 publications

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“…Indenopyrazoles have been found to be potent analgesics, antitubercular and anti-inflammatory agents, etc. Indenopyrazoles consist of indanedione moiety which may be responsible for their biological activities [34,35]. The Schiff bases have also been reported to be good complexing agents.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, characterization, in vitro antimicrobial and QSAR studies of diorganotin(IV) complexes of Schiff bases derived from 2-(3-methylbutanoyl)-1H-indene-1,3(2H)-dione and 4-substituted anilines

et al. 2018

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A series of some new diorganotin(IV) complexes [R 2 SnLCl] was synthesized by the reaction of 2-(3-methylbutanoyl)-1H-indene-1,3(2H)-dione and 4-substituted anilines (p-OCH 3 , p-NO 2 , p-CH 3 , p-Cl) with R 2 SnCl 2 , (R=Me, Et, n-Bu, Ph) in 1:1 molar ratio. The structure of the Schiff bases and their complexes were characterized by IR, 13 C, 1 H, 119 Sn NMR, and mass spectral techniques. The synthesized ligands and derived organotin complexes were evaluated in vitro against some bacterial strains, viz., Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus and fungal strains, viz., Aspergillus flavus, Aspergillus niger, and Candida albicans by serial dilution method. The antimicrobial results revealed that organotin complexes showed a distinct escalation in biocidal activity. Phenyl and butyl complexes were found to be more intoxicating. Furthermore, we performed QSAR studies which explained the different factors affecting the enhancement in the bioactivity of the complexes.

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Section: Resultsmentioning

confidence: 99%