Novel thiosemicarbazone derivatives and their metal complexes: Recent development

Structural study of Pt(II) and Pd(II) complexes with quinoline-2-carboxaldehyde thiosemicarbazone

“…3,4 However, the chelating capacity of thiosemicarbazones can be enhanced when additional suitable donor atoms are present in the molecule, as in the case of α-N-heterocyclic thiosemicarbazones. 3,4 As thiosemi-carbazones exist as thione-thiol tautomers, they can bind to a metal center in the neutral or the anionic forms. An overview on observed bonding modes for this class of ligands is given in several reviews in literature covering this filed.…”

“…[3][4][5] Thiosemicarbazone complexes have shown potent biological activity such as anticancer, antibacterial, antifungal, and antiviral owing to their property to diffuse through the semi permeable membrane of the cell lines. 2,[4][5][6] The enhanced effect of the complexes in comparison to free ligands may be attributed to the increased lipophilicity. Namely, upon coordination to the metal ion, the ligand orient with the lipophilic and aromatic parts outwards, exposing the hydrophobic part to the exterior.…”

Thiosemicarbazone Complexes of Transition Metals as Catalysts for Cross-Coupling Reactions

“…One of the primary motivations for research into these complexes has been the various areas in which they have been proposed for application. For example, apart from their activity as catalysts, which will be covered in more detail in this review, many thiosemicarbazone metal complexes have been widely studied as potential treatments for various types of cancer, for viral, bacterial, or fungal infections, and for neurodegenerative diseases, or for malaria [17][18][19][20][21][22][23][24][25][26]. Thiosemicarbazone metal complexes have also found potential application in medical imaging [27,28], while thiosemicarbazones themselves show promise as metal ion sensors and for the scavenging of metals due to their selective and specific coordination properties [28][29][30][31][32][33][34].…”

“…Another important aspect of thiosemicarbazones as ligands is the wide variety of coordination modes which can be adopted. Numerous structural studies have been carried out and this area has been the subject of a number of reviews [17,[53][54][55]. An equilibrium mixture of thione (I) and thiol (II) tautomers exists in solution (Scheme 1).…”

Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review

“…They can act as N, S-multidentate ligands, and moreover, it is possible to modulate the binding properties/stoichiometries through the insertion of other heteroatoms into the backbone structure (i.e., phenolic or pyridyl moieties). They have a great variety of biological properties, both as free ligands and as metal complexes, and several studies have been published reporting on thiosemicarbazone-based complexes with medicinal applications [12][13][14][15][16][17][18][19][20][21].…”