Synthesis and characterization of some new quinoline based derivatives endowed with broad spectrum antimicrobial potency

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

“…The activity of compounds was determined as per the National Committee for Clinical Laboratory Standards (NCCLS) protocol using Mueller-Hinton Broth (Becton-Dickinson, USA) [27,28,29,30]. All the newly synthesized compounds were evaluated against Gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenes), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) strains.…”

Synthesis of new pyrazoline-thiazoles and their biological activity

“…С целью расширения векторов использования 3,5-диарил-4,5- , дозволив ідентифікувати високо-активні сполуки з антимікробною [8][9][10][11][12][13], проти-вірусною [14,15], протизапальною [16], проти-пухлинною [17][18][19][20] 2+ використовувались похідні a-гало-генкарбонових кислот [8][9][10][11][12][13][14][15][16][17][18][19][20][21], малеїнової кисло-ти [15,23], β-ароїлакрилові кислоти [15], а також диметиловий естер ацетилендикарбонової кис-лоти [22] (рис.). Ефективне поєднання піразолі-нового та тіазолідинового фрагментів у контек-сті «гібрид-фармакофорного» підходу дозволило нам ідентифікувати перспективні протипухлин-ні, противірусні та антитрипаносомні сполуки-хіти [15,17,18,24].…”

Quinoline Based Monocarbonyl Curcumin Analogs as Potential Antifungal and Antioxidant Agents: Synthesis, Bioevaluation and Molecular Docking Study

“…It can be found in a variety of synthetic and natural antifungal drugs such as sitafloxacin and ciprofloxacin ( Figure ), suggesting the preference of nature for this scaffold and identifying it as one of medicinal chemistry's privileged structures. Specially, 2‐chloroquinoline based molecules are well‐known to exhibit various biological properties such as antimicrobial, anticancer, antifungal, antitubercular, DNA binding and photonuclease activity …”

“…It can be found in a variety of synthetic and natural antifungal drugs such as sitafloxacin and ciprofloxacin (Figure 2), suggesting the preference of nature for this scaffold and identifying it as one of medicinal chemistry's privileged structures. Specially, 2-chloroquinoline based molecules [34] are well-known to exhibit various biological properties such as antimicrobial, [35,36] anticancer, [37] antifungal, [38] antitubercular, [39] DNA binding and photonuclease activity. [40] Under this context and as a part of our ongoing research in the synthesis and biological evaluation of monocarbonyl curcumin analogs, [41][42][43] we would like to report herein the synthesis of 2-chloroquinolene based monocarbonyl curcumin analogs and their in vitro fungicidal and antioxidant activities.…”