Synthesis and characterization of sodium alginate conjugate and study of effect of conjugation on drug release from matrix tablet

Satheeshababu, B K; Mohamed, Ishraqa

doi:10.4103/0250-474x.169045

Cited by 14 publications

(4 citation statements)

References 3 publications

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“…To study the thermal behavior of CTX, OCT, CTX-OCT, and CTX-OCT-Alg, DSC measurements were conducted using a DSC-60 calorimeter (Shimadzu, Kyoto, Japan) 58 . DSC-60 was used for thermal analysis of CTX-OCT-Alg and their powders, sodium alginate powder and ca-alginate-beads.…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors

Abdellatif

Ibrahim

Amin

et al. 2020

Sci Rep

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There is a need to formulate oral cetuximab (CTX) for targeting colorectal cancer, which is reported to express somatostatin receptors (SSTRs). Therefore, coating CTX with a somatostatin analogue such as octreotide (OCT) is beneficial. Alginate was used to coat CTX to facilitate delivery to the gastrointestinal tract (GIT). This study aimed to deliver CTX conjugated with OCT in the form of microparticles as a GIT-targeted SSTR therapy. Both CTX and OCT were conjugated using a solvent evaporation method and the conjugated CTX-OCT was then loaded onto Ca-alginate-beads (CTX-OCT-Alg), which were characterized for drug interactions using differential scanning calorimetry (DSC), and Fourier transform infrared spectra (FTIR). Moreover, the morphology of formulated beads was examined using a scanning electron microscope (SEM). The drug content and release profile were studied using UV spectroscopy. Finally, in vitro cytotoxicity of all compounds was evaluated. The results showed homogenous conjugated CTX-OCT with a diameter of 0.4 mm. DSC showed a delay in the OCT peak that appeared after 200 °C due to small polymer interaction that shifted the OCT peak. Moreover, FTIR showed no prominent interaction. SEM showed clear empty cavities in the plain Ca-alginate-beads, while CTX-OCT-Alg showed occupied beads without cavities. CTX-OCT-Alg had a negligible release in 0.1 N HCl, while the CTX-OCT was completely released after 300 min in phosphate buffer pH 7.4. All formulations showed good antiproliferative activity compared with free drugs. The formulated CTX-OCT-Alg are a promising platform for targeting colorectal cancer through Git.Oral dosage forms of medications are generally a convenient dosage form for drug delivery 1,2 . However, one of the main challenges in drug delivery is to overcome gastric barriers and preventing the drug release in the stomach 3 . There was a huge increase in the development of orally delivered anti-cancer agents in the past 10 years, as a quarter of all available anti-cancer drugs are now administered orally 4 . Colorectal cancer is one of the most common forms of malignancy and the fourth most common contributor to cancer mortalities 5 . Moreover, targeting specific cells in cancer therapy provides an advantageous way to treat cancer directly 6-10 . For example, the release of drug in the colon and drug particles can be driven by octreotide (OCT) and bind to somatostatin receptors (SSTRs), which are a component of ligand-mediated targeting 8 . The inhibition effect of somatostatin (SST) analogues on tumor cells is one effective approach to cancer therapy. Moreover, SST and its analogues have open Scientific RepoRtS | (2020) 10:4736 | https://doi.org/10.1038/s41598-020-61605-y www.nature.com/scientificreports www.nature.com/scientificreports/ shown proliferative inhibition of colon cancer cell lines 11 . There are five subtypes of SSTRs expressed in colorectal cancer, and SSTR1 is the most prevalent compared to the others 12 .Cetuximab (CTX) is a recombinant monoclonal antibody drug used in the...

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Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors

Abdellatif

Ibrahim

Amin

et al. 2020

Sci Rep

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“…Differential Scanning Calorimetric was applied (Setaram instrument version Themys one + , Switzerland) to investigate any possible interactions between CTX, PEG 4000 and Glycerol [34]. Generally, DSC measures the temperatures and heat flows associated with transitions in materials as a function of time and temperature range (-4.9 to 489.9 °C) in a controlled atmosphere.…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

PEG-4000 formed polymeric nanoparticles loaded with cetuximab downregulate p21 & stathmin-1 gene expression in cancer cell lines

et al. 2022

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“…The ALG production from bacterial biosynthesis has definite physical characteristics and chemical structures different from the extracted ALG from brown seaweed. The different steps of ALG biosynthesis are (1) synthesis of the precursor substrate, (2) transfer polymerization and cytoplasmic membrane, (3) transport and alteration of the periplasmic membrane, and (4) conveying via the outer membrane [ 30 ].…”

Section: Sources Of Extraction and Properties Of Alginatementioning

confidence: 99%

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Abourehab

Singh

Pramanik

et al. 2022

IJMS

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Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are the colloidal polysaccharide group, which are water-soluble, non-toxic, and non-irritant. These are linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) and β-(1→4)-linked d-mannuronic acid (M) residues. Owing to the monosaccharide sequencing and the enzymatically governed reactions, alginates are well-known as an essential bio-polymer group for multifarious biomedical implementations. Additionally, alginate’s bio-adhesive property makes it significant in the pharmaceutical industry. Alginate has shown immense potential in wound healing and drug delivery applications to date because its gel-forming ability maintains the structural resemblance to the extracellular matrices in tissues and can be altered to perform numerous crucial functions. The initial section of this review will deliver a perception of the extraction source and alginate’s remarkable properties. Furthermore, we have aspired to discuss the current literature on alginate utilization as a biopolymeric carrier for drug delivery through numerous administration routes. Finally, the latest investigations on alginate composite utilization in wound healing are addressed.

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Synthesis and characterization of sodium alginate conjugate and study of effect of conjugation on drug release from matrix tablet

Cited by 14 publications

References 3 publications

Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors

Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors

PEG-4000 formed polymeric nanoparticles loaded with cetuximab downregulate p21 & stathmin-1 gene expression in cancer cell lines

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

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