Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

Abstract

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag)- and strontium (Sr)-doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ and Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in vitro bioactivity. The Ag-Sr MBGNs synthesized in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

Zn–Mn-Doped Mesoporous Bioactive Glass Nanoparticle-Loaded Zein Coatings for Bioactive and Antibacterial Orthopedic Implants

“…It is evident that Si and Ca initially release rapidly and then follow a relatively slow release rate. The Ca ion enhances the osteoconductive behavior of the MBGNs [ 41 ].…”

“…Zn–Mn-doped mesoporous bioactive glass nanoparticles (Zn–Mn-doped MBGNs) with nominal compositions of SiO 2 : 70 mol.%, CaO: 22 mol.%, Mn: 5 mol.%, and Zn: 3 mol.% were synthesized by the modified Stöber process [ 40 ]. The precursors, such as hexadecyltrimethylammonium bromide (CTAB)-98% (Sigma-Aldrich), zinc nitrate hexahydrate (Sigma-Aldrich), calcium nitrate (Avantor, Shanghai, China), manganese chloride (Uni-Chem, New Jersey, USA), tetraethyl orthosilicate (TEOS)-99% (Sigma-Aldrich), and ethyl acetate (99.5%, Merck, Darmstadt, Germany) were used to prepare MBGNs following the recipe obtained from our previous manuscript [ 41 ]. Briefly, a solution of distilled water (52 mL) and CTAB (1.12 g) was prepared by stirring (30 min) at room temperature.…”

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

“…Drugs incorporated with sodium ranelate assist in bone growth and bone density, and inhibit osteoclast cells. Strontium ranelate consists of ranelic acid which contains dual action bone agent (DABA) and provides favorable bone resorption and harmless effects [145]. Sr shows a beneficial response in various parts of the human body.…”

Mesoporous bioactive glasses for regenerative medicine

“…The doping of MBGs with ions of elements with biological activity, often denoted as therapeutic ions, is a subject investigated with great interest in recent years [ 70 , 71 ]. In these studies, the first objective is to determine the maximum amount of the extra oxide that can be incorporated into the MBG network to exert the desired biological action, but maintaining the necessary bioactivity, biocompatibility, and ordered mesoporosity.…”