Synthesis and characterization of silica aerogel as a promising drug carrier system

Mohammadian, Manijeh; Kashi, Tahereh Sadat Jafarzadeh; Erfan, Mohammad; Soorbaghi, Fatemeh Pashaei

doi:10.1016/j.jddst.2017.12.017

Cited by 38 publications

(21 citation statements)

References 34 publications

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“…In all FTIR spectrum of silica xerogel, characteristic peak corresponding to Si‐O−Si asymmetric stretching vibrations was observed at 1071 cm −1 . The peaks at 794 cm −1 and 456 cm −1 were related with Si‐O−Si symmetric stretching vibrations and bending mode, respectively . At about 2980 cm −1 and 2900 cm −1 , the peaks assigned to C−H stretching vibrations were determined with slightly different intensities.…”

Section: Resultsmentioning

confidence: 95%

Effect of Aging Solvents on Physicochemical and Thermal Properties of Silica Xerogels Derived from Steel Slag

Kaya¹,

Deveci²

2020

ChemistrySelect

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Silica xerogels were synthesized from steel slag by sol-gel method with ambient pressure drying. Effect of aging solvents (methanol, ethanol, n-propanol and isopropanol) on properties of silica xerogels was investigated. Formation of amorphous structure and silica network of silica xerogels was confirmed by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy analysis, respectively. Field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) analyses revealed highly porous structure silica xerogel aged in isopropanol. Specific surface area and pore volume of silica xerogels increased in the order: n-propanol < ethanol < methanol < isopropanol. Specific surface area of silica xerogel aged in isopropanol was 481 m 2 g À 1 . Thermogravimetric analysis (TGA) and differential thermal analysis (DTA) presented that highest thermal stability of silica xerogel was obtained in the presence of methanol. Lowest thermal conductivity and bulk density were specified with isopropanol as 0.046 g cm À 3 and 0.036 W m À 1 K À 1 .[a] G.

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Section: Resultsmentioning

confidence: 95%

Effect of Aging Solvents on Physicochemical and Thermal Properties of Silica Xerogels Derived from Steel Slag

Kaya¹,

Deveci²

2020

ChemistrySelect

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“…Compared with other research on loaded drugs similar to resveratrol (25%, 28%) [ 37 , 38 ], the loading rate of RSA (19%) is relatively low. This might be because some of the drugs diffuse from the inside due to the concentration difference during the post-gel solvent replacement process, which is obviously in the hydrogel.…”

Section: Discussionmentioning

confidence: 79%

“…The solution was more likely to penetrate the exposed section of the drug and released drug directly. While part of drug loading was on the aerogel, this step was eliminated, and the dissolution process was accelerated [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel

Qin

Zhao

et al. 2020

Molecules

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Silica aerogel, a kind of nanoporous material, is regarded as a desired drug carrier for its low toxicity, high specific surface area, and excellent biocompatibility. Using silica aerogel in a drug carrier may be an appropriate method to improve the performance of pure resveratrol. In this study, resveratrol-loaded silica aerogel (RSA) as a drug delivery system was prepared by the sol-gel method. Before gelling, resveratrol was added into the hydrolyzed tetraethyl orthosilicate (TEOS) ethanol solution then dispersed by stir and ultrasound. The results showed that RSA has a high loading rate of 19% with low cost and excellent biocompatibility. The SEM images showed that silica aerogel wraps up outside the resveratrol. Sustained releasing effect could be observed in RSA after 1 h, while pure resveratrol did not display this. The release of RSA lasted for over 6 h, and the release amount reached over 90% and 80% in either simulated gastric fluid (pH = 2.0) or phosphate-buffered saline (pH = 7.4) at 37 °C. Preliminary in vitro toxicity test revealed RSA to be biocompatible and stable; and when coupled with the anti-inflammatory effects of resveratrol, showed good potential for osteoarthritis treatment.

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“…Although the Occupational Safety and Health Agency (OSHA) described aerogels as a plausible irritant of the skin and upper airways [ 19 ], epidemiological and mechanistic studies on the plausible health effects of aerogels are scarce. Conversely, hybrid organic–inorganic aerogels are now being considered as a promising agent for targeted drug delivery, wound healing, and bone regeneration [ 35 , 36 , 37 ]. Therefore, whether aerogels impart beneficial or detrimental health effects needs to be understood through properly designed experimental and epidemiological research.…”

Section: Discussionmentioning

confidence: 99%

Non-Malignant Respiratory Illnesses in Association with Occupational Exposure to Asbestos and Other Insulating Materials: Findings from the Alberta Insulator Cohort

Moitra

Tabrizi

Machichi

et al. 2020

IJERPH

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Many insulating materials are used in construction, although few have been reported to cause non-malignant respiratory illnesses. We aimed to investigate associations between exposures to insulating materials and non-malignant respiratory illnesses in insulators. In this cross-sectional study, 990 insulators (45 ± 14 years) were screened from 2011–2017 in Alberta. All participants underwent pulmonary function tests and chest radiography. Demographics, work history, and history of chest infections were obtained through questionnaires. Chronic obstructive pulmonary disease (COPD) was diagnosed according to established guidelines. Associations between exposures and respiratory illnesses were assessed by modified Poisson regression. Of those screened, 875 (88%) were males. 457 (46%) participants reported having ≥ 1 chest infection in the past 3 years, while 156 (16%) were diagnosed with COPD. In multivariate models, all materials (asbestos, calcium silicate, carbon fibers, fiberglass, and refractory ceramic fibers) except aerogels and mineral fibers were associated with recurrent chest infections (prevalence ratio [PR] range: 1.18–1.42). Only asbestos was associated with COPD (PR: 1.44; 95% confidence interval [CI]: 1.01, 2.05). Therefore, occupational exposure to insulating materials was associated with non-malignant respiratory illnesses, specifically, recurrent chest infections and COPD. Longitudinal studies are urgently needed to assess the risk of exposure to these newly implemented insulation materials.

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Synthesis and characterization of silica aerogel as a promising drug carrier system

Cited by 38 publications

References 34 publications

Effect of Aging Solvents on Physicochemical and Thermal Properties of Silica Xerogels Derived from Steel Slag

Effect of Aging Solvents on Physicochemical and Thermal Properties of Silica Xerogels Derived from Steel Slag

Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel

Non-Malignant Respiratory Illnesses in Association with Occupational Exposure to Asbestos and Other Insulating Materials: Findings from the Alberta Insulator Cohort

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