Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel

Abstract

Silica aerogel, a kind of nanoporous material, is regarded as a desired drug carrier for its low toxicity, high specific surface area, and excellent biocompatibility. Using silica aerogel in a drug carrier may be an appropriate method to improve the performance of pure resveratrol. In this study, resveratrol-loaded silica aerogel (RSA) as a drug delivery system was prepared by the sol-gel method. Before gelling, resveratrol was added into the hydrolyzed tetraethyl orthosilicate (TEOS) ethanol solution then dispersed by stir and ultrasound. The results showed that RSA has a high loading rate of 19% with low cost and excellent biocompatibility. The SEM images showed that silica aerogel wraps up outside the resveratrol. Sustained releasing effect could be observed in RSA after 1 h, while pure resveratrol did not display this. The release of RSA lasted for over 6 h, and the release amount reached over 90% and 80% in either simulated gastric fluid (pH = 2.0) or phosphate-buffered saline (pH = 7.4) at 37 °C. Preliminary in vitro toxicity test revealed RSA to be biocompatible and stable; and when coupled with the anti-inflammatory effects of resveratrol, showed good potential for osteoarthritis treatment.

Silver Fir (Abies alba L.) Polyphenolic Extract Shows Beneficial Influence on Chondrogenesis In Vitro under Normal and Inflammatory Conditions

“…One of the possibilities to provide appropriate concentrations of these substances at sites of the damaged joints, and in particular in the cartilage, is the use of specific biomaterials such as silica aerogel. Indeed, it has been shown that resveratrol-loaded silica aerogel is biocompatible and stable, and that when it is coupled with the anti-inflammatory effects of resveratrol, it showed good potential for osteoarthritis treatment [ 30 ]. Based on our results, Belinal is a strong candidate to be tested with the same strategy.…”

Insights on toxicity, safe handling and disposal of silica aerogels and amorphous nanoparticles

“…Moreover, the dusty feature of silica aerogel particles can particularly produce a dry sensation in the skin and irritation by friction. [88][89][90][91][92][93][94][95][96][97] 99 Sol-gel and supercritical drying/SA: 470 to 750 m 2 g −1…”

“…Environmental Science: Nano Critical review Silica aerogels and hybrid aerogels containing silica have been tested regarding cytocompatibility with several cell lines (adipose tissue, fibroblasts, blood, neurons, osteoblasts, keratinocytes, endothelial cells, chondrocytes, tumour cells). 91,93,95,[97][98][99][100][101][102][103] In general, silica-based aerogels presented good cytocompatibility with cell viabilities above 90% (Table 3) and have been even proposed as scaffolds to promote cell growth and proliferation for the ultimate goal of tissue growth or as artificial heart valve leaflets. [94][95][96]98,102,104 Silica aerogels have been also proposed as a non-cytotoxic and safe carrier or vector of different drugs (resveratrol, 5-fluorouracil, paclitaxel, methotrexate) for local and systemic administrations.…”

“…[94][95][96]98,102,104 Silica aerogels have been also proposed as a non-cytotoxic and safe carrier or vector of different drugs (resveratrol, 5-fluorouracil, paclitaxel, methotrexate) for local and systemic administrations. [91][92][93]97 Interestingly, the biological response of some hybrid aerogels can differ from the behaviour of their individual counterparts. 99 The incorporation of increasing contents of hydroxyapatite (HA) in silica aerogel networks at weight ratios up to 1.3 also resulted in higher viabilities and growth of fibroblasts and osteoblasts than those of silica aerogel and hydroxyapatite individually, following increasing trends up to 0.5 where a maximum was reached.…”

A Review on Revolutionary Natural Biopolymer-Based Aerogels for Antibacterial Delivery

“…Controlled release of loaded antibacterial materials is essential. It has been reported that drug release is limited by the skeletal structure of the aerogel; such that the release rate decreases with the prolongation of release time [ 83 ]. Wang et al [ 84 ] reported that the change in the ratio of ingredients of the precursor materials would result in the aerogels with ordered pore structures and stable properties.…”