Synthesis and characterization of selenium substituted hydroxyapatite via a hydrothermal procedure

Fe3+/− dual doped nano hydroxyapatite: A novel material for biomedical applications

“…The surface of SeHA and Fe-SeHA materials was entirely covered with crystals of apatite structure without any bare area as shown in Figure 6(c-e). SEM examinations showed that dual doping of HA with Fe 31 /SeO 4 22 ions increased the surface reactivity and, as a result, apatite layer covered the entire surface of SeHA and Fe-SeHA materials. Higher apatite layer deposition on 2Fe-SeHA material surface was observed, which suggests that incorporation of FIGURE 6.…”

“…The total amount of serum proteins adsorbed on HA disc was found as 21 mg protein/g pellet. With the incorporation of Fe 31 /SeO 4 22 ions in HA structure, a significant increase in serum protein adsorption was observed, indicating a faster protein adsorption on Fe-SeHA samples compared to pure HA. This behavior might be attributed to the strong electrostatic interaction between the negative charge of serum proteins and Fe 31 /Ca 21 ions (positive ions) on the surface of Fe-SeHA materials.…”

“…20 Moreover, other studies reported that Fe-HA materials were non-toxic and they showed improved bioactivity, hemocompatibility, and osteointegration compared to phase pure HA. 21,22 Inspired by above reports in the literature on the beneficial role of Se and Fe ions, the incorporation of Fe 31 and SeO 4 22 into HA should have a considerable influence on the physicochemical properties of HA crystals and its biological properties. According to our best of knowledge, codoping of HA with Fe 31 and SeO 4 22 ions has not been reported yet.…”

“…3 There are two sites in the synthetic HA where ionic substitutions can occur. These sites include Ca 21 and PO 4 32/ OH 2 . Mono ion substitutions in HA have already been reported in the literature.…”

“…Mono ion substitutions in HA have already been reported in the literature. [4][5][6] Dual and triple ions doping may also be beneficial to improve the properties of synthetic HA and such substitutions are receiving huge attention by researchers nowadays. Recently, dual ions substituted HA has been synthesized as a new biomaterial and it showed improved properties for the biomedical applications.…”