Synthesis and structure properties of Se and Sr co-doped hydroxyapatite and their biocompatibility

Wei, Luxi; Heng, Y.; Hong, Jiadan; He, Zhihuan; Deng, Chunlin

doi:10.1007/s10853-018-2951-7

Cited by 33 publications

(23 citation statements)

References 40 publications

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“…At the initial stage of deposition (<60 min), HA crystals nucleate on the braid surface; after nuclei completely covers with the surface of PVA/PLA braid (>60 min), HA crystals begin to grow, and then aggregated to a smooth plate-like plane; when deposited for long time (>90 min), circular HA particles are formed on the plate-like plane again, resulting in a slight increase in roughness (Figure 5E) [45,46]. The hydroxyl radicals produced by electrolysis react with phosphate and calcium ions to form HA immediately.…”

Section: Resultsmentioning

confidence: 99%

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Ling

Lin

et al. 2019

Nanomaterials

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Hydroxyapatite (HA) coating is successfully prepared by electrodeposition on the surface of polyvinyl alcohol (PVA)/polylactic acid (PLA) braid which serves as a potential biodegradable bone scaffold. The surface morphology, element composition, crystallinity and chemical bonds of HA coatings at various deposition times (60, 75, 90, 105 and 120 min) are characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), respectively. Average Surface roughness (Ra) of HA coating is observed by confocal microscopy. The results reveal that the typical characteristic peaks of the FTIR spectrum confirm that HA coating is successfully prepared on the rugged surface of the PVA/PLA braid. The XRD results indicate that the crystallinity of HA can be improved by increasing deposition time. In the 90 min-deposition, hydroxyapatite has a dense and uniform coating morphology, Ca/P ratio of 1.7, roughness of 0.725 μm, which shows the best electrodeposition performance. The formation mechanism of granular and plate-like hydroxyapatite crystals is explained by the structural characteristics of a hydroxyapatite unit cell. This study provides a foundation for a bone scaffold braided by biodegradable fibers.

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Section: Resultsmentioning

confidence: 99%

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Ling

Lin

et al. 2019

Nanomaterials

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“…Liu et al [ 23 ] found that Sr 2+ incorporation in coralline HA significantly improves osteo-conductivity and inductivity. Wei et al [ 24 ] reported the synthesis of hydroxyapatite co-doped with selenium and strontium ions, but they did not study the antibacterial properties. Zhang et al [ 25 ] synthesized Si-Sr co-substituted HA and reported that compared to mono-substituted Si-HA and Sr-HA, di-substituted HA had better biological properties and the ability to stimulate cell attachment and proliferation of osteoblasts and mesenchymal stem cells.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Antibacterial Properties, and In Vitro Studies of Selenium and Strontium Co-Substituted Hydroxyapatite

Maqbool

Nawaz

Rehman

et al. 2021

IJMS

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In this study, as a measure to enhance the antimicrobial activity of biomaterials, the selenium ions have been substituted into hydroxyapatite (HA) at different concentration levels. To balance the potential cytotoxic effects of selenite ions (SeO32−) in HA, strontium (Sr2+) was co-substituted at the same concentration. Selenium and strontium-substituted hydroxyapatites (Se-Sr-HA) at equal molar ratios of x Se/(Se + P) and x Sr/(Sr + Ca) at (x = 0, 0.01, 0.03, 0.05, 0.1, and 0.2) were synthesized via the wet precipitation route and sintered at 900 °C. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and cell viability were studied. X-ray diffraction verified the phase purity and confirmed the substitution of selenium and strontium ions. Acellular in vitro bioactivity tests revealed that Se-Sr-HA was highly bioactive compared to pure HA. Se-Sr-HA samples showed excellent antibacterial activity against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus carnosus) bacterial strains. In vitro cell–material interaction, using human osteosarcoma cells MG-63 studied by WST-8 assay, showed that Se-HA has a cytotoxic effect; however, the co-substitution of strontium in Se-HA offsets the negative impact of selenium and enhanced the biological properties of HA. Hence, the prepared samples are a suitable choice for antibacterial coatings and bone filler applications.

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“…Figure 6 illustrates the XRD spectra of the spray-dried and heat-treated SD-HA and SD-HA-Gel microgranules. The XRD spectrum of SD-HA (Figure 6A) presented characteristic diffraction peaks at 2 25.4°, 31.7°, 34° and 39.8° matches with the (002), ( 211), ( 202) and (310) crystalline planes of HA phase (PDF 09-432 XRD card), respectively [52,53]. In the available literature, it was reported that the effect of gelatin on the crystal structure of the HA was multifold: Gelatin reduced the crystallinity/crystal size of the HA nanoparticles when it was added during the precipitation of HA [54].…”

Section: Resultsmentioning

confidence: 95%

PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS

Baştan

2021

Eskişehir Technical University Journal of Science and Technology a - Applied Sciences and Engineering

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In this study, composite hydroxyapatite (HA)-gelatin microspheres (SD-HA-Gel) were produced for bone substitution applications. The polymer network within the HA matrix would be facilitated as a drug carrier system and can develop the cellmicrosphere interactions due to the excellent biological properties of gelatin. Gelatin functionalized HA microspheres and bare HA granules (as a reference) with 8 µm average size were produced by spray drying process. The morphology, thermal properties, chemical and phase structure of the produced powders were analyzed by SEM, TG-DTA, FTIR and XRD methods. SD-HA-Gel microspheres presented spherical morphology and hollow/core-shell cross-section and consisted of HA nanoparticles and gelatin molecules together according to the SEM, FTIR and XRD studies. Thermal analyze results showed that gelatin evolved from the microspheres at ~300 °C. The effect of gelatin on the crystallization and high temperature stability of HA was studied by XRD analysis and Rietveld Refinement investigations. Gelatin was released from the microspheres after immersion for 14 days in phosphate buffer saline (PBS) solution.

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Synthesis and structure properties of Se and Sr co-doped hydroxyapatite and their biocompatibility

Cited by 33 publications

References 40 publications

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Synthesis, Characterization, Antibacterial Properties, and In Vitro Studies of Selenium and Strontium Co-Substituted Hydroxyapatite

PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS

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