Synthesis and characterization of Schiff base containing bovine serum albumin-gum arabic aldehyde hybrid nanogels via inverse miniemulsion for delivery of anticancer drug

Bashiri, Ghazal; Shojaosadati, Seyed Abbas; Abdollahi, Mahdi

doi:10.1016/j.ijbiomac.2020.12.150

Cited by 30 publications

(13 citation statements)

References 36 publications

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“…The kinetic release results at pH 1.2 and 7.4 showed that the diffusion phenomenon was mainly followed during the drug release. The low n values, i.e., <0.45 calculated by the Korsmeyer Peppas model and K d /K r in Peppas-Sahlin affirmed the mediation of drug release by diffusion which is in agreement with published literature (Table 4b) [50][51][52].…”

Section: Nanoparticlessupporting

confidence: 89%

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pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation

Noreen

Hasan

Ghumman

et al. 2022

IJMS

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The rapid progression in biomaterial nanotechnology apprehends the potential of non-toxic and potent polysaccharide delivery modules to overcome oral chemotherapeutic challenges. The present study is aimed to design, fabricate and characterize polysaccharide nanoparticles for methotrexate (MTX) delivery. The nanoparticles (NPs) were prepared by Abelmoschus esculentus mucilage (AEM) and chitosan (CS) by the modified coacervation method, followed by ultra-sonification. The NPs showed much better pharmaceutical properties with a spherical shape and smooth surface of 213.4–254.2 nm with PDI ranging between 0.279–0.485 size with entrapment efficiency varying from 42.08 ± 1.2 to 72.23 ± 2.0. The results revealed NPs to possess positive zeta potential and a low polydispersity index (PDI). The in-vitro drug release showed a sustained release of the drug up to 32 h with pH-dependence. Blank AEM -CS NPs showed no in-vivo toxicity for a time duration of 14 days, accompanied by high cytotoxic effects of optimized MTX loaded NPs against MCF-7 and MD-MBA231 cells by MTT assay. In conclusion, the findings advocated the therapeutic potential of AEM/CS NPs as an efficacious tool, offering a new perspective for pH-responsive routing of anticancer drugs with tumor cells as a target.

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Section: Nanoparticlessupporting

confidence: 89%

“…In this scenario, the diffusion dominates in accord with K d and K r values as the K d /K r ratio is >1. The “n” values range between 0.43 and 0. indicates an anomalous diffusion drug release too ( Table 4 a) [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation

Noreen

Hasan

Ghumman

et al. 2022

IJMS

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“…Although serum albumins have been less explored than fibrous proteins to design chemically crosslinked hydrogels with stimuli-responsive properties, they are emerging as excellent candidates for biomaterials due to their inherent biocompatibility. 203 For example, a series of stimuli-responsive Schiff base-linked hydrogels for applications in biocatalysis and biosensing were reported using both HSA and BSA. 141 BSA has also been incorporated in nanostructure templates for biosensing the insecticide methyl parathion, 204 nanoparticles for controlled CUR delivery, 205 and non-ionic surfactant drug-delivery vesicles.…”

Section: Schiff Base-linked Protein Hydrogelsmentioning

confidence: 99%

Dynamic protein and polypeptide hydrogels based on Schiff base co-assembly for biomedicine

et al. 2022

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“…This drug was released from the nanogel via a host-guest molecular recognition [92]. A study demonstrated that bovine serum albumin-gum arabic aldehyde (BSA-GAA) containing 5-fluorouracil responded to the pH changes and the high level of drugs were released at lower pH and inhibited the growth of MCF-7 breast cancer cells [93]. Other than drug delivery for cancer therapy, vancomycin-loaded DNA nanogels were made to deliver antibiotics.…”

Section: Delivery Of Drugsmentioning

confidence: 99%

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Pushpamalar

Meganathan

Tan

et al. 2021

Gels

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Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.

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Synthesis and characterization of Schiff base containing bovine serum albumin-gum arabic aldehyde hybrid nanogels via inverse miniemulsion for delivery of anticancer drug

Cited by 30 publications

References 36 publications

pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation

pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation

Dynamic protein and polypeptide hydrogels based on Schiff base co-assembly for biomedicine

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

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