Synthesis and characterization of PVP microneedle patch using metal bioelectrodes for novel drug delivery system

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

“…The reason for the popularity of 3D printing technology has been attribut to the tunability and versatility that facilitates the personalized fabrication of physic models of the desired geometric shape with computer-aided design and computer-aid manufacturing [160][161][162]. This prototyping technology is based on layer-by-layer printi and superposition that provides high accuracy along with good reproducibility [163,16 The most current and commonly utilized manufacturing technologies of 3D printing clude inkjet printing, photopolymerization-based technique, and fused deposition mo eling (FDM) for fabricating polymeric MNs [160,162,[164][165][166][167]. Figure 9 [162] shows t steps for fabricating MN devices using 3D printing technology.…”

“…Without disturbing the nerves of the underlying dermis and destroying blood vessels, MNs may also be optimized to enter the specified depths in the skin [ 15 ]. Thus, MN therapy allows for a minimally invasive molecule delivery into the skin, unlike the traditional methods for transdermal delivery of pharmaceuticals [ 16 ].…”

A study on the high efficiency reduction of p-nitrophenol (4-NP) by a Fe(OH)3/Fe2O3@Au composite catalyst

“…Because MES has good metal affinity, the addition of MES can coordinate with Au nanoparticles and act as a stabilizer for these nanoparticles. 38,39 On this basis, the possible formation mechanism of Fe(OH) 3 /Fe 2 O 3 @Au is proposed. In previous reports, Zhang and colleagues have demonstrated that there is a key reaction intermediate in the formation of ultra-thin a-Co(OH) 2 nanosheets-Co-B composite nanospheres.…”

“…By consulting the literature, it is found that polyvinyl pyrrolidone (PVP) and morpholine ethanesulfonic acid (MES) have good metal affinity, especially MES. [38][39][40][41] Therefore, PVP and MES can be used as stabilizers of Au NPs to form complexes with Fe(OH) 3 /Fe 2 O 3 nanosheets. 40 In this study, single atom-dispersed Au nanoparticles were loaded on the support material of ultra-thin Fe(OH) 3 /Fe 2 O 3 nanosheets via a green one-step method.…”

Advances of Microneedles in Biomedical Applications

“…A “Web of Science” search with the topic of “microneedle” yielded 3407 articles published since 2000 ( Figure 3 ), which indicates the rapid increase of microneedle studies. Moreover, most microneedles are applied in biomedical areas, especially for cancer therapy, skin disease therapy, insulin delivery for diabetes treatment, blood glucose level detection and vaccines [ 17 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Therefore, in this work, we mainly review the classification, manufacture and biomedical applications of microneedles.…”